Phenotypes associated with this allele

• Allele Symbol: Slc17a6^tm1Lex
• Allele Name: targeted mutation 1, Lexicon Genetics
• Allele ID: MGI:3693887
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Slc17a6^tm1Lex/Slc17a6^tm1Lex	involves: 129S5/SvEvBrd * C57BL/6	MGI:3694783
ht2	Slc17a6^tm1Lex/Slc17a6^+	involves: 129S5/SvEvBrd * C57BL/6	MGI:3694784

Genotype
MGI:3694783

hm1

• Allelic Composition: Slc17a6^tm1Lex/Slc17a6^tm1Lex
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:116159 )

• die at or immediately after birth

respiratory system

respiratory failure ( J:116159 )

• fail to begin breathing

nervous system

abnormal CNS synaptic transmission ( J:116159 )

• in thalmic neurons the readily releasable vesicle pool charge following application of hypertonic sucrose is 16.1 +/- 3.5 pC compared to 211 +/- 39 pC in wild-type mice

abnormal excitatory postsynaptic currents ( J:116159 )

• 21% of thalmic non-GABAergic neurons show no evoked response

increased excitatory postsynaptic current amplitude ( J:116159 )

• amplitudes in thalmic neurons average 91 +/- 16 pA compared to 2.44 +/- 0.33 nA in wild-type mice

decreased miniature excitatory postsynaptic current amplitude ( J:116159 )

• thalmic miniature EPSC amplitude is reduced by about 50% compared to wild-type mice

decreased miniature excitatory postsynaptic current frequency ( J:116159 )

• thalmic miniature EPSC frequency is reduced by greater than 90% compared to wild-type mice

behavior/neurological

abnormal motor capabilities/coordination/movement ( J:116159 )

• fail to respond to forceps stimulation after cesarean delivery

Genotype
MGI:3694784

ht2

• Allelic Composition: Slc17a6^tm1Lex/Slc17a6⁺
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

nervous system

abnormal miniature excitatory postsynaptic currents ( J:116159 )

• thalmic miniature EPSC amplitude is intermediate between wild-type and homozygous mice

behavior/neurological

abnormal conditioned taste aversion behavior ( J:116159 )

• time to extinction with repeated exposures is shorter in especially in low-responder heterozygotes compared to wild-type mice

abnormal locomotor activation ( J:116159 )

• bury fewer marbles; however activity in the home cage and results in the open field, rotarod, elevated plus maze, social interaction, passive avoidance learning, Morris water maze, and context-dependent fear conditioning tests are all similar to wild-type mice

abnormal pain threshold ( J:116159 )

• in the spared nerve injury model of neuropathic pain mechanical allodynia is absent in males and significantly reduced in females compared to wild-type mice

• in the spared nerve injury model of neuropathic pain cold allodynia is absent in females and significantly reduced in males compared to wild-type mice