Phenotypes associated with this allele

• Allele Symbol: aol
• Allele Name: ankylotic osteoarthritis lesions
• Allele ID: MGI:3693920
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	aol/aol	involves: C3H * C57BL/6	MGI:3694663

Genotype
MGI:3694663

hm1

• Allelic Composition: aol/aol
• Genetic Background: involves: C3H * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

limbs/digits/tail

fused tarsal bones ( J:115238 )

abnormal ankle joint morphology ( J:115238 )

• instability and changes at the ankle joint are exhibited starting at 9 months of age in some mutants and in most by 14 months of age with progressing severity; 87% of male and 21% of female mutants are affected

mortality/aging

premature death ( J:115238 )

• most mutants die by 22 months of age

behavior/neurological

abnormal gait ( J:115238 )

• at 20 months of age, mutants display tiptoe walking

paresis ( J:115238 )

• at 20 months of age, mutants may display motor paresis

skeleton

joint swelling ( J:115238 )

• swollen ankle joints are observed

osteoarthritis ( J:115238 )

• progressive anklyotic osteoarthritic lesions develop in homozygotes, usually starting at ~14 months of age

fused tarsal bones ( J:115238 )

abnormal ankle joint morphology ( J:115238 )

• instability and changes at the ankle joint are exhibited starting at 9 months of age in some mutants and in most by 14 months of age with progressing severity; 87% of male and 21% of female mutants are affected

abnormal cartilage morphology ( J:115238 )

• marked ossification of extra-articular soft tissue at the ankle occurs at 20 months

• early in observed osteoarthritic pathology, surface of cartilage is rough and thinning, with detectable fissures in cartilage layers

ectopic cartilage ( J:115238 )

• cartilaginous hyperplastic tissues bridge articular cavities, and subsequently ossify

abnormal synovial joint capsule morphology ( J:115238 )

• bone spurs are observed as cartilaginous projections from periosteal tissues subjacent to synovial-articular cartilage junction

abnormal synovial joint membrane morphology ( J:115238 )

• severely affected ankle joints appear to have lost synovial lining

fused joints ( J:115238 )

• ankle joints show fusion of tarsal bones, bridging between calcaneous and metatarsal bones at 20 months; 87% of male and 21% of female mutants are affected

immune system

osteoarthritis ( J:115238 )

• progressive anklyotic osteoarthritic lesions develop in homozygotes, usually starting at ~14 months of age

pigmentation

abnormal coat/hair pigmentation ( J:115238 )

• mutants have a different coat color than normal (color - yellowish-brown, not agouti); not determined if this is secondary to joint phenotype or due to another genetic mutation

integument

abnormal coat/hair pigmentation ( J:115238 )

• mutants have a different coat color than normal (color - yellowish-brown, not agouti); not determined if this is secondary to joint phenotype or due to another genetic mutation

homeostasis/metabolism

joint swelling ( J:115238 )

• swollen ankle joints are observed