Phenotypes associated with this allele

• Allele Symbol: Lyl1^tm1Fsky
• Allele Name: targeted mutation 1, Fred Sablitzky
• Allele ID: MGI:3693950
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lyl1^tm1Fsky/Lyl1^tm1Fsky	involves: 129P2/OlaHsd * C57BL/6	MGI:3694640

Genotype
MGI:3694640

hm1

• Allelic Composition: Lyl1^tm1Fsky/Lyl1^tm1Fsky
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:173665 )

N • myeloid and lymphoid cell numbers are normal in adults

decreased pro-B cell number ( J:116300 )

• mice have reduced numbers of stem/progenitor B cells

arrested B cell differentiation ( J:116300 )

• a partial block in differentiation is observed after the pro-B stage

abnormal T cell differentiation ( J:116300 )

• when mutant bone marrow is transplanted into irradiated recipients, reconstitution of T cell lineage is impaired

thrombocytopenia ( J:173665 )

• platelet cell numbers are significantly reduced in adults

decreased B cell number ( J:116300 )

• markedly reduced (1-3-fold) in peripheral blood, bone marrow and spleen in adults

abnormal hematopoietic stem cell physiology ( J:173665 )

• stem cells with a limited ability to engraft recipients noticed by 4 weeks

• repopulation is skewed toward myeloid cells

• short term repopulation potential is somewhat greater than in Lyl1^tm1Mago

immune system

decreased pro-B cell number ( J:116300 )

• mice have reduced numbers of stem/progenitor B cells

arrested B cell differentiation ( J:116300 )

• a partial block in differentiation is observed after the pro-B stage

abnormal T cell differentiation ( J:116300 )

• when mutant bone marrow is transplanted into irradiated recipients, reconstitution of T cell lineage is impaired

decreased B cell number ( J:116300 )

• markedly reduced (1-3-fold) in peripheral blood, bone marrow and spleen in adults