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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Trpc2tm1Mom
targeted mutation 2, Peter Mombaerts
MGI:3694003
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Trpc2tm1Mom/Trpc2tm1Mom B6.129P2-Trpc2tm1Mom/Zuf MGI:6380000
cx2
 		Gucy1b2tm3Mom/Gucy1b2tm3Mom
Trpc2tm1Mom/Trpc2tm1Mom 		involves: 129P2/OlaHsd * C57BL/6J MGI:5804187


Genotype
MGI:6380000
hm1
Allelic
Composition		 Trpc2tm1Mom/Trpc2tm1Mom
Genetic
Background		 B6.129P2-Trpc2tm1Mom/Zuf
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trpc2tm1Mom mutation (1 available); any Trpc2 mutation (98 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal behavior ( J:279957 )
• due to the lack of vomeronasal perception of f-MKKFRW, homozygotes fail to display the normal avoidance behaviour to this core peptide of an enteric bacterial virulence regulator

nervous system
abnormal vomeronasal sensory neuron physiology ( J:279957 )
• fail to respond to the f-MKKFRW peptide, which is the core peptide motif from the enteric bacterial master virulence regulator MgrB




Genotype
MGI:5804187
cx2
Allelic
Composition		 Gucy1b2tm3Mom/Gucy1b2tm3Mom
Trpc2tm1Mom/Trpc2tm1Mom
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gucy1b2tm3Mom mutation (1 available); any Gucy1b2 mutation (33 available)
Trpc2tm1Mom mutation (1 available); any Trpc2 mutation (98 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal physiological response to hypoxia ( J:235858 , J:307157 )
• type B olfactory sensory neurons fail to respond to reduced oxygen although they respond normally to 8-bromo-cGMP and KCl (J:235858)
• type B olfactory sensory neurons respond to NaHS but fail to respond to reduced oxygen (J:307157)

taste/olfaction

behavior/neurological
abnormal sensory capabilities/reflexes/nociception ( J:235858 )
• n a conditioned place aversion test to an area of low oxygen these homozygotes fail to display a preference away from the low oxygen area consistent with the failure of type B olfactory sensory neurons to respond to low oxygen

nervous system
nervous system phenotype ( J:235858 )
N
• homozygotes have a normal hyperventilation response to a 10% oxygen environment

respiratory system




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
06/12/2024
MGI 6.13 		The Jackson Laboratory