Phenotypes associated with this allele

• Allele Symbol: Catsper4^tm1Clph
• Allele Name: targeted mutation 1, David E Clapham
• Allele ID: MGI:3694354
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Catsper4^tm1Clph/Catsper4^tm1Clph	involves: 129S4/SvJae	MGI:3694474

Genotype
MGI:3694474

hm1

• Allelic Composition: Catsper4^tm1Clph/Catsper4^tm1Clph
• Genetic Background: involves: 129S4/SvJae

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

teratozoospermia ( J:116406 )

♂ • maximal bending angle of principal bend in midpiece of flagellum is 49% compared to 92% in wild-type

impaired sperm capacitation ( J:116406 )

♂ • many capacitated sperm cells that can not hyperactivate motility exhibit decreased bending in midpiece of proximal flagellum

male infertility ( J:116406 )

♂ • males mated with wild-type females sire no litters

abnormal sperm physiology ( J:116406 )

♂ • calcium-selective pH sensitive sperm current (I_CatSper) is not detectable

abnormal sperm motility ( J:116406 )

♂ • percent motility of mutant sperm decreases more rapidly than wild-type

asthenozoospermia ( J:116406 )

♂ • after 90 minutes in viscous conditions, sperm lose their motility compared to wild-type which move more vigorously than initially

cellular

teratozoospermia ( J:116406 )

♂ • maximal bending angle of principal bend in midpiece of flagellum is 49% compared to 92% in wild-type

abnormal sperm motility ( J:116406 )

♂ • percent motility of mutant sperm decreases more rapidly than wild-type

asthenozoospermia ( J:116406 )

♂ • after 90 minutes in viscous conditions, sperm lose their motility compared to wild-type which move more vigorously than initially