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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Apba3tm1.1Sud
targeted mutation 1.1, Thomas C Sudhof
MGI:3694704
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Apba3tm1.1Sud/Apba3tm1.1Sud involves: 129S1/Sv * 129X1/SvJ MGI:3697718
cn2
 		Apba1tm1.1Sud/Apba1tm1.1Sud
Apba3tm1.1Sud/Apba3tm1.1Sud 		involves: 129S1/Sv * 129X1/SvJ MGI:3694738
cn3
 		Apba1tm1.1Sud/Apba1tm1.1Sud
Apba2tm1.1Sud/Apba2tm1.1Sud
Apba3tm1.1Sud/Apba3tm1.1Sud 		involves: 129S1/Sv * 129X1/SvJ MGI:3694739


Genotype
MGI:3697718
cn1
Allelic
Composition		 Apba3tm1.1Sud/Apba3tm1.1Sud
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apba3tm1.1Sud mutation (0 available); any Apba3 mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:115573 )
• mutants are viable and fertile




Genotype
MGI:3694738
cn2
Allelic
Composition		 Apba1tm1.1Sud/Apba1tm1.1Sud
Apba3tm1.1Sud/Apba3tm1.1Sud
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apba1tm1.1Sud mutation (0 available); any Apba1 mutation (32 available)
Apba3tm1.1Sud mutation (0 available); any Apba3 mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, incomplete penetrance ( J:115573 )
• born in normal ratio; double mutants display survival deficit, with only ~20% survival postnatal
• hours after birth, pups have no milk in their stomachs, become progressively weaker within twelve hours, and die within 24 hours




Genotype
MGI:3694739
cn3
Allelic
Composition		 Apba1tm1.1Sud/Apba1tm1.1Sud
Apba2tm1.1Sud/Apba2tm1.1Sud
Apba3tm1.1Sud/Apba3tm1.1Sud
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apba1tm1.1Sud mutation (0 available); any Apba1 mutation (32 available)
Apba2tm1.1Sud mutation (0 available); any Apba2 mutation (45 available)
Apba3tm1.1Sud mutation (0 available); any Apba3 mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, incomplete penetrance ( J:115573 )
• triple mutants display survival deficit, with only ~20% survival postnatal
• hours after birth, pups have no milk in their stomachs, become progressively weaker within twelve hours, and die within 24 hours

nervous system
abnormal CNS synaptic transmission ( J:115573 )
• mice display decreased basal synaptic strength compared to Apba1-null mice
• in culture, when neonatal neurons homozygous for floxed Apba1, Apba2 and Apba3 alleles are treated with lentiviral cre, a ~30% reduction in miniature spontaneous current frequency in both excitatory and inhibitory synapses compared to control neurons
• synaptic response to hypertonic sucrose application is significantly decreased
abnormal inhibitory postsynaptic currents ( J:115573 )
• in response to hypertonic sucrose, currents are decreased ~45% in cultured, cre-treated neurons
• use-dependent depression in initially decreased at excitatory synapses during repetitive 10 Hz stimulation




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory