Phenotypes associated with this allele

• Allele Symbol: Amelx^tm1Msnd
• Allele Name: targeted mutation 1, Malcolm L Snead
• Allele ID: MGI:3694786
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Amelx^tm1Msnd/Amelx^tm1Msnd	involves: 129X1/SvJ	MGI:3695921
ht2	Amelx^tm1Msnd/Amelx^+	involves: 129X1/SvJ	MGI:3695922

Genotype
MGI:3695921

hm1

• Allelic Composition: Amelx^tm1Msnd/Amelx^tm1Msnd
• Genetic Background: involves: 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Enamel architecture changes in Amelx^tm1Msnd/Amelx^tm1Msnd and Amelx^tm2Msnd/Amelx^tm2Msnd mice

craniofacial

abnormal molar cusp morphology ( J:116448 )

♀ • 6-week molars display a shallow cusp structure

abnormal enamel morphology ( J:116448 )

♀ • at 4 days of age, 15-20 nm nanospheres of amelogenin are absent

abnormal ameloblast morphology ( J:116448 )

♀ • Tomes' processes are shorter and alpha 6 integrin expression is restricted to the flat apical membrane

short Tomes' process ( J:116448 )

♀ • Tomes' processes are shorter

abnormal enamel rod pattern ( J:116448 )

♀ • lack woven rods of crystallites

♀ • rod organization is disrupted and rod and interrod boundary features are absent

reduced enamel thickness ( J:116448 )

♀ • reduced thickness and more easily abraded

abnormal tooth wear ( J:116448 )

♀ • enamel is more prone to fracture and more easily abraded with mastication

brittle teeth ( J:116448 )

♀ • incisors fracture during chewing

♀ • enamel is more prone to fracture

skeleton

abnormal molar cusp morphology ( J:116448 )

♀ • 6-week molars display a shallow cusp structure

abnormal enamel morphology ( J:116448 )

♀ • at 4 days of age, 15-20 nm nanospheres of amelogenin are absent

abnormal ameloblast morphology ( J:116448 )

♀ • Tomes' processes are shorter and alpha 6 integrin expression is restricted to the flat apical membrane

short Tomes' process ( J:116448 )

♀ • Tomes' processes are shorter

abnormal enamel rod pattern ( J:116448 )

♀ • lack woven rods of crystallites

♀ • rod organization is disrupted and rod and interrod boundary features are absent

reduced enamel thickness ( J:116448 )

♀ • reduced thickness and more easily abraded

abnormal tooth wear ( J:116448 )

♀ • enamel is more prone to fracture and more easily abraded with mastication

brittle teeth ( J:116448 )

♀ • incisors fracture during chewing

♀ • enamel is more prone to fracture

growth/size/body

abnormal molar cusp morphology ( J:116448 )

♀ • 6-week molars display a shallow cusp structure

abnormal enamel morphology ( J:116448 )

♀ • at 4 days of age, 15-20 nm nanospheres of amelogenin are absent

abnormal ameloblast morphology ( J:116448 )

♀ • Tomes' processes are shorter and alpha 6 integrin expression is restricted to the flat apical membrane

short Tomes' process ( J:116448 )

♀ • Tomes' processes are shorter

abnormal enamel rod pattern ( J:116448 )

♀ • lack woven rods of crystallites

♀ • rod organization is disrupted and rod and interrod boundary features are absent

reduced enamel thickness ( J:116448 )

♀ • reduced thickness and more easily abraded

abnormal tooth wear ( J:116448 )

♀ • enamel is more prone to fracture and more easily abraded with mastication

brittle teeth ( J:116448 )

♀ • incisors fracture during chewing

♀ • enamel is more prone to fracture

Genotype
MGI:3695922

ht2

• Allelic Composition: Amelx^tm1Msnd/Amelx⁺
• Genetic Background: involves: 129X1/SvJ

craniofacial

abnormal enamel rod pattern ( J:116448 )

♀ • sections of abnormal rod pattern next to sections of normal rod pattern resulting from X inactivation of either the mutant or wild-type allele

brittle teeth ( J:116448 )

♀ • enamel fractures

growth/size/body

abnormal enamel rod pattern ( J:116448 )

♀ • sections of abnormal rod pattern next to sections of normal rod pattern resulting from X inactivation of either the mutant or wild-type allele

brittle teeth ( J:116448 )

♀ • enamel fractures

skeleton

abnormal enamel rod pattern ( J:116448 )

♀ • sections of abnormal rod pattern next to sections of normal rod pattern resulting from X inactivation of either the mutant or wild-type allele

brittle teeth ( J:116448 )

♀ • enamel fractures