Phenotypes associated with this allele

• Allele Symbol: Amelx^tm2Msnd
• Allele Name: targeted mutation 2, Malcolm L Snead
• Allele ID: MGI:3694787
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Amelx^tm2Msnd/Amelx^tm2Msnd	involves: 129X1/SvJ	MGI:3695923
ht2	Amelx^tm2Msnd/Amelx^+	involves: 129X1/SvJ	MGI:3695924

Genotype
MGI:3695923

hm1

• Allelic Composition: Amelx^tm2Msnd/Amelx^tm2Msnd
• Genetic Background: involves: 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Enamel architecture changes in Amelx^tm1Msnd/Amelx^tm1Msnd and Amelx^tm2Msnd/Amelx^tm2Msnd mice

craniofacial

abnormal molar crown morphology ( J:116448 )

♀ • accelerated wear

abnormal enamel morphology ( J:116448 )

♀ • amelogenin nanospheres are larger than in wild-type mice

♀ • enamel crystallites have irregular size and organization

abnormal ameloblast morphology ( J:116448 )

♀ • Tomes' processes are shorter and alpha 6 integrin expression is distributed at multiple foci in the secretory end piece

short Tomes' process ( J:116448 )

♀ • Tomes' processes are shorter

abnormal enamel rod pattern ( J:116448 )

♀ • arrangement and size of rods are abnormal

♀ • weaving of the matrix is reduced

reduced enamel thickness ( J:116448 )

♀ • reduced thickness and more easily abraded

abnormal tooth wear ( J:116448 )

♀ • molars show accelerated wear

♀ • enamel is more prone to fracture and more easily abraded with mastication

brittle teeth ( J:116448 )

♀ • incisors are fragile with incisal edge fractures during chewing

skeleton

abnormal molar crown morphology ( J:116448 )

♀ • accelerated wear

abnormal enamel morphology ( J:116448 )

♀ • amelogenin nanospheres are larger than in wild-type mice

♀ • enamel crystallites have irregular size and organization

abnormal ameloblast morphology ( J:116448 )

♀ • Tomes' processes are shorter and alpha 6 integrin expression is distributed at multiple foci in the secretory end piece

short Tomes' process ( J:116448 )

♀ • Tomes' processes are shorter

abnormal enamel rod pattern ( J:116448 )

♀ • arrangement and size of rods are abnormal

♀ • weaving of the matrix is reduced

reduced enamel thickness ( J:116448 )

♀ • reduced thickness and more easily abraded

abnormal tooth wear ( J:116448 )

♀ • molars show accelerated wear

♀ • enamel is more prone to fracture and more easily abraded with mastication

brittle teeth ( J:116448 )

♀ • incisors are fragile with incisal edge fractures during chewing

growth/size/body

abnormal molar crown morphology ( J:116448 )

♀ • accelerated wear

abnormal enamel morphology ( J:116448 )

♀ • amelogenin nanospheres are larger than in wild-type mice

♀ • enamel crystallites have irregular size and organization

abnormal ameloblast morphology ( J:116448 )

♀ • Tomes' processes are shorter and alpha 6 integrin expression is distributed at multiple foci in the secretory end piece

short Tomes' process ( J:116448 )

♀ • Tomes' processes are shorter

abnormal enamel rod pattern ( J:116448 )

♀ • arrangement and size of rods are abnormal

♀ • weaving of the matrix is reduced

reduced enamel thickness ( J:116448 )

♀ • reduced thickness and more easily abraded

abnormal tooth wear ( J:116448 )

♀ • molars show accelerated wear

♀ • enamel is more prone to fracture and more easily abraded with mastication

brittle teeth ( J:116448 )

♀ • incisors are fragile with incisal edge fractures during chewing

Genotype
MGI:3695924

ht2

• Allelic Composition: Amelx^tm2Msnd/Amelx⁺
• Genetic Background: involves: 129X1/SvJ

craniofacial

abnormal enamel rod pattern ( J:116448 )

♀ • sections of abnormal rod pattern next to sections of normal rod pattern resulting from X inactivation of either the mutant or wild-type allele

brittle teeth ( J:116448 )

♀ • enamel fractures

growth/size/body

abnormal enamel rod pattern ( J:116448 )

♀ • sections of abnormal rod pattern next to sections of normal rod pattern resulting from X inactivation of either the mutant or wild-type allele

brittle teeth ( J:116448 )

♀ • enamel fractures

skeleton

abnormal enamel rod pattern ( J:116448 )

♀ • sections of abnormal rod pattern next to sections of normal rod pattern resulting from X inactivation of either the mutant or wild-type allele

brittle teeth ( J:116448 )

♀ • enamel fractures