Phenotypes associated with this allele

• Allele Symbol: Tg(Syn1-ADCY7)11004Btab
• Allele Name: transgene insertion 11004, Boris Tabakoff
• Allele ID: MGI:3695128
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Syn1-ADCY7)11004Btab/0	B6.Cg-Tg(Syn1-ADCY7)11004Btab	MGI:3695129
tg2	Tg(Syn1-ADCY7)11004Btab/0	involves: C57BL/6 * SJL	MGI:3695130

Genotype
MGI:3695129

tg1

• Allelic Composition: Tg(Syn1-ADCY7)11004Btab/0
• Genetic Background: B6.Cg-Tg(Syn1-ADCY7)11004Btab

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavioral despair ( J:116184 )

• females but not males display increased immobility in the forced swim and tail suspension tests

• however, no difference in anxiety related behaviors is seen compared to wild-type mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
melancholic depression		DOID:1595	OMIM:608516	J:116184

Genotype
MGI:3695130

tg2

• Allelic Composition: Tg(Syn1-ADCY7)11004Btab/0
• Genetic Background: involves: C57BL/6 * SJL

behavior/neurological

abnormal behavioral response to xenobiotic ( J:116797 )

• develop greater morphine tolerance with low levels of chronic daily treatment (5mg/kg) and with higher morphine concentrations (10 mg/kg) develop tolerance earlier compared to wild-type mice

increased chemically-elicited antinociception ( J:116797 )

• significantly lower morphine ED50 in the hot plate test; however, basal paw-lick latency is similar to wild-type mice