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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(CD2-Ceacam1*4L)1Rsb
transgene insertion 1, Richard S Blumberg
MGI:3695215
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Tg(CD2-Ceacam1*4L)1Rsb/0
Tg(TcraTcrb)425Cbn/0 		involves: BALB/c * C57BL/6 MGI:3695218
tg2
 		Tg(CD2-Ceacam1*4L)1Rsb/0 involves: C57BL/6 MGI:3695219


Genotype
MGI:3695218
cx1
Allelic
Composition		 Tg(CD2-Ceacam1*4L)1Rsb/0
Tg(TcraTcrb)425Cbn/0
Genetic
Background		 involves: BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(CD2-Ceacam1*4L)1Rsb mutation (0 available)
Tg(TcraTcrb)425Cbn mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal CD4-positive, alpha-beta T cell physiology ( J:116136 )
• CD4+ spleen cells exhibit decreased proliferation and IL-2 production in response to OVA (ovalbumin) and OVA peptide compared to Tg(TcraTcrb)425Cbn mice

hematopoietic system
abnormal CD4-positive, alpha-beta T cell physiology ( J:116136 )
• CD4+ spleen cells exhibit decreased proliferation and IL-2 production in response to OVA (ovalbumin) and OVA peptide compared to Tg(TcraTcrb)425Cbn mice




Genotype
MGI:3695219
tg2
Allelic
Composition		 Tg(CD2-Ceacam1*4L)1Rsb/0
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased T cell number ( J:116136 )
• a decrease in CD3+ T cell population in total splenocytes is observed
abnormal T cell physiology ( J:116136 )
• transgene expression increases the amount of Ceacam1 on the surface of transgenic cells in the thymus and in peripheral lymph nodes, but not in intestinal epithelial lymphocytes (iIEL)
• cells are less responsive than wild-type cells in a mixed lymphocyte response (MLR) assay
• cells exhibit decreased contact sensitivity response to oxazolone
decreased T cell proliferation ( J:116136 )
• cells show lower proliferation compared to wild-type

immune system
decreased T cell number ( J:116136 )
• a decrease in CD3+ T cell population in total splenocytes is observed
abnormal T cell physiology ( J:116136 )
• transgene expression increases the amount of Ceacam1 on the surface of transgenic cells in the thymus and in peripheral lymph nodes, but not in intestinal epithelial lymphocytes (iIEL)
• cells are less responsive than wild-type cells in a mixed lymphocyte response (MLR) assay
• cells exhibit decreased contact sensitivity response to oxazolone
decreased T cell proliferation ( J:116136 )
• cells show lower proliferation compared to wild-type
decreased interleukin-2 secretion ( J:116136 )
• transgenic T cells produce less IL-2 than wild-type with anti-CD3 and -CD28 stimulation

cellular
decreased T cell proliferation ( J:116136 )
• cells show lower proliferation compared to wild-type




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory