Analysis Tools
immune system
small thymus
(
J:116964
)
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• at 4 weeks of age; however, thymus size increases with age
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• at 4 weeks of age
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• increase in the total number of B and T cells by 4 weeks of age
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• partial block in T cell development, with most cells stopping at double negative stage 3
• however, unlike in Lat single homozygotes some T cell do make it past the double negative stage
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• at 10 weeks of age the double positive cell population is practically absent from the thymus
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• a 3- to 20-fold increase in the ratio of CD4 to CD8 cells is seen in cells from the spleen and lymph nodes at 4 weeks of age
• increase in CD4 to CD8 ratio is larger in older mice
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• T cell organization is disrupted
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• high rate of splenocyte proliferation in the absence of stimulation; however, with stimulation proliferation level is similar to wild-type indicating no increase in maximal proliferative capacity
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• a decrease in the proportion of resting B cell and an increase in the proportion of activated B cells is seen in the spleen
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• marked increase in IgG1 but no significant differences in the levels of IgG2a, IgG2b, IgG3 or IgA compared to wild-type mice
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• moderately increased
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• production of IFNG is seen only after stimulation with phorbol myristate acetate (PMA) and ionomycin and not when splenocytes are stimulated with anti-CD3 and anti-CD28
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• production of IL-2 is seen only after stimulation with PMA and ionomycin and not when splenocytes are stimulated with anti-CD3 and anti-CD28
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• increased splenocyte production of IL-10 after stimulation with PMA and ionomycin
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• splenocytes produce large amounts of IL-4
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hematopoietic system
small thymus
(
J:116964
)
|
• at 4 weeks of age; however, thymus size increases with age
|
|
• at 4 weeks of age
|
|
• increase in the total number of B and T cells by 4 weeks of age
|
|
• partial block in T cell development, with most cells stopping at double negative stage 3
• however, unlike in Lat single homozygotes some T cell do make it past the double negative stage
|
|
• at 10 weeks of age the double positive cell population is practically absent from the thymus
|
|
• a 3- to 20-fold increase in the ratio of CD4 to CD8 cells is seen in cells from the spleen and lymph nodes at 4 weeks of age
• increase in CD4 to CD8 ratio is larger in older mice
|
|
• T cell organization is disrupted
|
|
• high rate of splenocyte proliferation in the absence of stimulation; however, with stimulation proliferation level is similar to wild-type indicating no increase in maximal proliferative capacity
|
|
• a decrease in the proportion of resting B cell and an increase in the proportion of activated B cells is seen in the spleen
|
|
• marked increase in IgG1 but no significant differences in the levels of IgG2a, IgG2b, IgG3 or IgA compared to wild-type mice
|
|
• moderately increased
|
endocrine/exocrine glands
small thymus
(
J:116964
)
|
• at 4 weeks of age; however, thymus size increases with age
|
growth/size/body
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• at 4 weeks of age
|
|
• increase in the total number of B and T cells by 4 weeks of age
|
