Phenotypes associated with this allele

• Allele Symbol: Napepld^tm1Crv
• Allele Name: targeted mutation 1, Benjamin F Cravatt
• Allele ID: MGI:3695401
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Napepld^tm1Crv/Napepld^tm1Crv	involves: 129X1/SvJ * C57BL/6	MGI:3695743
cx2	Gde1^tm1Crv/Gde1^tm1Crv Napepld^tm1Crv/Napepld^tm1Crv	involves: 129X1/SvJ * C57BL/6	MGI:5583870

Genotype
MGI:3695743

hm1

• Allelic Composition: Napepld^tm1Crv/Napepld^tm1Crv
• Genetic Background: involves: 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal nervous system physiology ( J:108301 )

• brain levels of saturated and monounsaturated, but not polyunsaturated, N-acyl ethanolamines (NAE) are significantly reduced, especially the very long chain saturated NAEs

• brain levels of saturated and monounsaturated, but not polyunsaturated, N-acyl phosphatidylethanolamines are increased

• however, mice are viable and healthy with no obvious abnormalities in home cage behavior

Genotype
MGI:5583870

cx2

• Allelic Composition: Gde1^tm1Crv/Gde1^tm1Crv; Napepld^tm1Crv/Napepld^tm1Crv
• Genetic Background: involves: 129X1/SvJ * C57BL/6

homeostasis/metabolism

abnormal enzyme/coenzyme activity ( J:213193 )

• brain homogenates lack conversion of N-acyl phosphatidyl ethanolamine to N-acyl ethanolamine

• treatment with an FAAH inhibitor fail to result in accumulation N-acyl ethanolamine in the brain

• however, N-acyl ethanolamine bulk levels in the brain is normal