Analysis Tools|
Allele Symbol Allele Name Allele ID |
Map4k1tm1Tht targeted mutation 1, Tse-Hua Tan MGI:3695423 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• in the experimental autoimmune encephalitis (EAE) model, mutants are more susceptible, demonstrating severe fore- and hindlimb paralysis and greater infiltration of brain tissues by CD4+ T cells than do wild-type animals; T cells proliferate more and produce greater amounts of interferon than wild-type
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• T cells cultured with irradiated splenocytes are hyperproliferative in response to CD3 stimulation
• in absence of costimulation from antigen-presenting cells, stimulation with anti-CD3 and anti-CD28 induces more cell divisions in cultured mutant cells compared to wild-type cells
• in vivo, stimulation with a T cell-dependent antigen, keyhole limpet hemocyanin (KLH) induces more T cell proliferation in mutants than in wild-type
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• sera in mutants contain more antigen-specific antibodies during primary and secondary immunizations
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• mutant T cells produce more IL-2 and IL-4, as well as interferon-gamma in vivo in response to keyhole limpet hemocyanin (KLH) stimulation
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• T cells cultured with irradiated splenocytes are hyperproliferative in response to CD3 stimulation
• in absence of costimulation from antigen-presenting cells, stimulation with anti-CD3 and anti-CD28 induces more cell divisions in cultured mutant cells compared to wild-type cells
• in vivo, stimulation with a T cell-dependent antigen, keyhole limpet hemocyanin (KLH) induces more T cell proliferation in mutants than in wild-type
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• T cells cultured with irradiated splenocytes are hyperproliferative in response to CD3 stimulation
• in absence of costimulation from antigen-presenting cells, stimulation with anti-CD3 and anti-CD28 induces more cell divisions in cultured mutant cells compared to wild-type cells
• in vivo, stimulation with a T cell-dependent antigen, keyhole limpet hemocyanin (KLH) induces more T cell proliferation in mutants than in wild-type
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/17/2024 MGI 6.24 |
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