All Phenotypes Ndfip1<Gt(RRD002)Byg> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ndfip1^{Gt(RRD002)Byg}/Ndfip1^{Gt(RRD002)Byg}	involves: 129P2/OlaHsd	MGI:5550270
hm2	Ndfip1^{Gt(RRD002)Byg}/Ndfip1^{Gt(RRD002)Byg}	involves: 129P2/OlaHsd * C57BL/6	MGI:3695608
cx3	Il4^tm1Cgn/Il4^tm1Cgn Ndfip1^{Gt(RRD002)Byg}/Ndfip1^{Gt(RRD002)Byg}	involves: 129P2/OlaHsd	MGI:5550267
cx4	Cd28^tm1Mak/Cd28^tm1Mak Ndfip1^{Gt(RRD002)Byg}/Ndfip1^{Gt(RRD002)Byg}	involves: 129P2/OlaHsd * 129S2/SvPas	MGI:5550269
cx5	Ndfip1^{Gt(RRD002)Byg}/Ndfip1^{Gt(RRD002)Byg} Rag1^tm1Mom/Rag1^tm1Mom Tg(TcraTcrb)425Cbn/0	involves: 129P2/OlaHsd * 129S7/SvEvBrd * BALB/c * C57BL/6	MGI:5550271

Allelic Composition	Ndfip1^{Gt(RRD002)Byg}/Ndfip1^{Gt(RRD002)Byg}
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ndfip1^{Gt(RRD002)Byg} mutation (0 available); any Ndfip1 mutation (14 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased activated T cell number ( J:205692 )

• in the spleen

abnormal T cell physiology ( J:205692 )

• T cells are less dependent on CD28 costimulation than control cells

increased T cell proliferation ( J:205692 )

• following T cell activation in the absence of CD28 costimulation

• regardless of whether IL2 blocking antibodies are present or not

increased interleukin-2 secretion ( J:205692 )

• following T cell activation in the absence of CD28 costimulation

hematopoietic system

increased activated T cell number ( J:205692 )

• in the spleen

abnormal T cell physiology ( J:205692 )

• T cells are less dependent on CD28 costimulation than control cells

increased T cell proliferation ( J:205692 )

• following T cell activation in the absence of CD28 costimulation

• regardless of whether IL2 blocking antibodies are present or not

cellular

increased T cell proliferation ( J:205692 )

• following T cell activation in the absence of CD28 costimulation

• regardless of whether IL2 blocking antibodies are present or not

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:116617 )

• some mice die shortly after weaning

• dramatic decrease in survival beginning around 10 weeks of age with no mice survive more than 14 weeks

immune system

increased spleen weight ( J:116617 )

• spleen to body weight ratio is 16.9 +/- 2.7 mg/g compared to 3.4 +/- 0.5 mg/g in wild-type mice

increased activated T cell number ( J:116617 )

• more T cells express CD4 and are activated

abnormal T cell physiology ( J:116617 )

increased T cell proliferation ( J:116617 )

• following TCR stimulation; however, in the absence of stimulation cells do not divide (similar to wild-type cells)

abnormal T-helper 2 physiology ( J:116617 )

• in Th2-polarizing conditions T cells are more likely to produce IL-4 compared to wild-type cells

increased inflammatory response ( J:116617 )

lung inflammation ( J:116617 )

• signs of inflammation including goblet cell hyperplasia and inflammatory infiltrate in perivascular regions

dermatitis ( J:116617 )

• by 6 weeks of age some mice develop skin lesions on their ears and by 8 weeks of age all mice have these lesions

• inflammation contains a predominantly eosinophilic and lymphocytic inflitrate

hematopoietic system

increased spleen weight ( J:116617 )

• spleen to body weight ratio is 16.9 +/- 2.7 mg/g compared to 3.4 +/- 0.5 mg/g in wild-type mice

extramedullary hematopoiesis ( J:116617 )

• seen in the liver and spleen

abnormal bone marrow cell number ( J:116617 )

• bone marrow contains fewer B cells, more myeloid lineage cells, and similar numbers of pre-erythroid cells compared to wild-type mice

increased activated T cell number ( J:116617 )

• more T cells express CD4 and are activated

abnormal T cell physiology ( J:116617 )

increased T cell proliferation ( J:116617 )

• following TCR stimulation; however, in the absence of stimulation cells do not divide (similar to wild-type cells)

abnormal T-helper 2 physiology ( J:116617 )

• in Th2-polarizing conditions T cells are more likely to produce IL-4 compared to wild-type cells

liver/biliary system

abnormal bile duct morphology ( J:116617 )

• intrahepatic bile ducts

abnormal liver morphology ( J:116617 )

• intrahepatic bile ducts

increased liver weight ( J:116617 )

• liver to body weight ratio is 101 +/- 11 mg/g compared to 48 +/- 4 mg/g in wild-type mice

limbs/digits/tail

abnormal tail morphology ( J:116617 )

• tail becomes segmented in appearance over time

short tail ( J:116617 )

• tails tend to be shorter

growth/size/body

cachexia ( J:116617 )

• develops shortly after the appearance of skin lesions

increased liver weight ( J:116617 )

• liver to body weight ratio is 101 +/- 11 mg/g compared to 48 +/- 4 mg/g in wild-type mice

increased spleen weight ( J:116617 )

• spleen to body weight ratio is 16.9 +/- 2.7 mg/g compared to 3.4 +/- 0.5 mg/g in wild-type mice

respiratory system

lung inflammation ( J:116617 )

• signs of inflammation including goblet cell hyperplasia and inflammatory infiltrate in perivascular regions

endocrine/exocrine glands

abnormal bile duct morphology ( J:116617 )

• intrahepatic bile ducts

integument

dermatitis ( J:116617 )

• by 6 weeks of age some mice develop skin lesions on their ears and by 8 weeks of age all mice have these lesions

• inflammation contains a predominantly eosinophilic and lymphocytic inflitrate

cellular

increased T cell proliferation ( J:116617 )

• following TCR stimulation; however, in the absence of stimulation cells do not divide (similar to wild-type cells)

Allelic Composition	Il4^tm1Cgn/Il4^tm1Cgn Ndfip1^{Gt(RRD002)Byg}/Ndfip1^{Gt(RRD002)Byg}
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il4^tm1Cgn mutation (4 available); any Il4 mutation (46 available)
Ndfip1^{Gt(RRD002)Byg} mutation (0 available); any Ndfip1 mutation (14 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:205692 )

• due to inflammatory disease

immune system

increased eosinophil cell number ( J:205692 )

• increased percent in esophagus and lung mucosal tissues

increased neutrophil cell number ( J:205692 )

• increased percent in esophagus and lung mucosal tissues

increased T cell number ( J:205692 )

• increased percent in esophagus and lung mucosal tissues

increased CD4-positive, alpha-beta T cell number ( J:205692 )

• increased percent in esophagus and lung mucosal tissues

increased interleukin-2 secretion ( J:205692 )

• compared with Il4^tm1Cgn homozygotes

increased inflammatory response ( J:205692 )

• at 12, but not 6, weeks

esophageal inflammation ( J:205692 )

lung inflammation ( J:205692 )

digestive/alimentary system

esophageal epithelium hyperplasia ( J:205692 )

esophageal inflammation ( J:205692 )

respiratory system

lung inflammation ( J:205692 )

lung epithelium hyperplasia ( J:205692 )

hematopoietic system

increased eosinophil cell number ( J:205692 )

• increased percent in esophagus and lung mucosal tissues

increased neutrophil cell number ( J:205692 )

• increased percent in esophagus and lung mucosal tissues

increased T cell number ( J:205692 )

• increased percent in esophagus and lung mucosal tissues

increased CD4-positive, alpha-beta T cell number ( J:205692 )

• increased percent in esophagus and lung mucosal tissues

Allelic Composition	Cd28^tm1Mak/Cd28^tm1Mak Ndfip1^{Gt(RRD002)Byg}/Ndfip1^{Gt(RRD002)Byg}
Genetic Background	involves: 129P2/OlaHsd * 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd28^tm1Mak mutation (12 available); any Cd28 mutation (52 available)
Ndfip1^{Gt(RRD002)Byg} mutation (0 available); any Ndfip1 mutation (14 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

esophageal inflammation ( J:205692 )

• later with lesser eosinophil infiltration than in Ndfip1^{Gt(RRD002)Byg} homozygotes

increased eosinophil cell number ( J:205692 )

• in the small bowel, but not esophagus

increased interleukin-2 secretion ( J:205692 )

• following T cell activation

increased interleukin-4 secretion ( J:205692 )

• following T cell activation

digestive/alimentary system

abnormal esophageal epithelium morphology ( J:205692 )

• epithelial hypertrophy in the esophagus

esophageal inflammation ( J:205692 )

• later with lesser eosinophil infiltration than in Ndfip1^{Gt(RRD002)Byg} homozygotes

hematopoietic system

increased eosinophil cell number ( J:205692 )

• in the small bowel, but not esophagus

Allelic Composition	Ndfip1^{Gt(RRD002)Byg}/Ndfip1^{Gt(RRD002)Byg} Rag1^tm1Mom/Rag1^tm1Mom Tg(TcraTcrb)425Cbn/0
Genetic Background	involves: 129P2/OlaHsd * 129S7/SvEvBrd * BALB/c * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ndfip1^{Gt(RRD002)Byg} mutation (0 available); any Ndfip1 mutation (14 available)
Rag1^tm1Mom mutation (49 available); any Rag1 mutation (123 available)
Tg(TcraTcrb)425Cbn mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:205692 )

N	• unlike Ndfip1^{Gt(RRD002)Byg} homozygotes, mice do not develop eosinophilic inflammation and T cells do not acquire an activated phenotype in the absence of antigen

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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