Phenotypes associated with this allele

• Allele Symbol: Rspo3^tm1Okam
• Allele Name: targeted mutation 1, Hitoshi Okamoto
• Allele ID: MGI:3695687
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rspo3^tm1Okam/Rspo3^tm1Okam	involves: 129P2/OlaHsd	MGI:3696850

Genotype
MGI:3696850

hm1

• Allelic Composition: Rspo3^tm1Okam/Rspo3^tm1Okam
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:116978 )

• present at E11.5 but none are born alive

• growth arrest around E10.5

embryo

embryonic growth arrest ( J:116978 )

• arrest around E10.5

decreased embryo size ( J:116978 )

• visible starting around E10.5

abnormal placenta labyrinth morphology ( J:116978 )

• at E9.5 the branched morphology is absent and the chorioallantoic interface remains flat until E11.5

• reduced thickness at E11.5

• however, spongiotrophoblast and trophoblast giant cells appear normal

abnormal placental labyrinth vasculature morphology ( J:116978 )

• fetal vessels do not lie adjacent to the maternal blood sinus

• fetal vessels fail to penetrate the labyrinth layer

growth/size/body

decreased embryo size ( J:116978 )

• visible starting around E10.5

cardiovascular system

abnormal placental labyrinth vasculature morphology ( J:116978 )

• fetal vessels do not lie adjacent to the maternal blood sinus

• fetal vessels fail to penetrate the labyrinth layer