Phenotypes associated with this allele

• Allele Symbol: Tg(SOD1*)125Dbo
• Allele Name: transgene insertion 125, David Borschelt
• Allele ID: MGI:3695897
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(SOD1*)125Dbo/?	involves: C3H/HeJ * C57BL/6J	MGI:5056450

Genotype
MGI:5056450

tg1

• Allelic Composition: Tg(SOD1*)125Dbo/?
• Genetic Background: involves: C3H/HeJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

hindlimb paralysis ( J:86421 )

• mice develop hindlimb paralysis by 8-12 months of age

nervous system

decreased motor neuron number ( J:86421 )

neuronal intranuclear inclusions ( J:86421 )

• inclusion bodies are detected in spinal cord and brainstem

• inclusions are present at low levels in cerebral cortex and cerebellum

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
amyotrophic lateral sclerosis type 1		DOID:0060193	OMIM:105400	J:86421