Phenotypes associated with this allele

• Allele Symbol: Snx13^tm1.1Frq
• Allele Name: targeted mutation 1, Marilyn G Farquhar
• Allele ID: MGI:3696045
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Snx13^tm1.1Frq/Snx13^tm1.1Frq	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3696427

Genotype
MGI:3696427

hm1

• Allelic Composition: Snx13^tm1.1Frq/Snx13^tm1.1Frq
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Snx13^tm1.1Frq/Snx13^tm1.1Frq embryos are smaller, show defects in neural tube closure, vasculogenesis and placental morphology

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:117102 )

• die at midgestation, between E10.5 and E13.5

growth/size/body

decreased embryo size ( J:117102 )

• smaller between E8.5 and E13.5

embryo

decreased embryo size ( J:117102 )

• smaller between E8.5 and E13.5

open neural tube ( J:117102 )

• frequently display failure of neural tube closure; at E10.5-11.5, often show everted, open cranial neural folds

abnormal extraembryonic tissue morphology ( J:117102 )

abnormal placenta morphology ( J:117102 )

abnormal trophoblast giant cell morphology ( J:117102 )

• trophoblast cells have large nuclei and abundant granular cytoplasm, which often is more eosinophilic than in wild-type

abnormal placenta labyrinth morphology ( J:117102 )

• failure of labyrinthine trophoblast differentiation

abnormal placental labyrinth vasculature morphology ( J:117102 )

• labyrinthine vessels often appear wider than in wild-type, suggesting a defect in branching morphogenesis

• reduction in maternal vascular spaces in the labyrinthine layer

small placenta ( J:117102 )

• by E11.5-E13.5, the placentas are smaller

abnormal extraembryonic endoderm formation ( J:117102 )

• visceral yolk sac endoderm contains abnormal endosomal compartments and the presence of autophagic vacuoles

cardiovascular system

abnormal blood vessel morphology ( J:117102 )

• show an abnormal cephalic vascularization that is less arborized than in wild-type

abnormal capillary morphology ( J:117102 )

• the number of capillaries in the anterior and posterior aspects of the neural folds that fail to close is small and the general organization of the capillary network is irregular

abnormal placental labyrinth vasculature morphology ( J:117102 )

• labyrinthine vessels often appear wider than in wild-type, suggesting a defect in branching morphogenesis

• reduction in maternal vascular spaces in the labyrinthine layer

nervous system

open neural tube ( J:117102 )

• frequently display failure of neural tube closure; at E10.5-11.5, often show everted, open cranial neural folds