Phenotypes associated with this allele

• Allele Symbol: Gfi1^tm1.1Wep
• Allele Name: targeted mutation 1.1, William E Paul
• Allele ID: MGI:3696050
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gfi1^tm1.1Wep/Gfi1^tm1.1Wep	B6.129-Gfi1^tm1.1Wep	MGI:3696770

Genotype
MGI:3696770

hm1

• Allelic Composition: Gfi1^tm1.1Wep/Gfi1^tm1.1Wep
• Genetic Background: B6.129-Gfi1^tm1.1Wep

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body size ( J:117105 )

• usually have small body size

hematopoietic system

small thymus ( J:117105 )

• reduced size likely due to block in T cell development

thymus hypoplasia ( J:117105 )

• reduced to ~14% of thymi of wild-type

arrested T cell differentiation ( J:117105 )

• developmental blockage from double negative 1 (DN1) to DN2 is seen

decreased B cell number ( J:117105 )

• modest reduction in percentage of B cells in spleen is observed

immune system

small thymus ( J:117105 )

• reduced size likely due to block in T cell development

thymus hypoplasia ( J:117105 )

• reduced to ~14% of thymi of wild-type

arrested T cell differentiation ( J:117105 )

• developmental blockage from double negative 1 (DN1) to DN2 is seen

decreased B cell number ( J:117105 )

• modest reduction in percentage of B cells in spleen is observed

endocrine/exocrine glands

small thymus ( J:117105 )

• reduced size likely due to block in T cell development

thymus hypoplasia ( J:117105 )

• reduced to ~14% of thymi of wild-type