cellular
• after adenoviral cre infection, OSE cells in culture show significantly higher sensitivity to cisplatin treatment compared to control cells (47.3% remain ater 48 hours compared to 66.2% of control cells remaining)
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• cultured cre-infected ovarian surface epithelium (OSE) cells show slower growth than GFP-injected cells at 96 and 120 hours post injection; at 120 hours, cell numbers are decreased by 40% compared to controls
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endocrine/exocrine glands
• after adenoviral-cre-mediated recombination in the ovarian surface epithelium, significantly greater morphological changes are observed compared to controls receiving adenoviral GFP injection
• there a 4-fold more epithelial invaginations in cre-injected ovaries than in GFP-injected controls at 240 days post-injection
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reproductive system
• after adenoviral-cre-mediated recombination in the ovarian surface epithelium, significantly greater morphological changes are observed compared to controls receiving adenoviral GFP injection
• there a 4-fold more epithelial invaginations in cre-injected ovaries than in GFP-injected controls at 240 days post-injection
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