Phenotypes associated with this allele

• Allele Symbol: Ercc2^tm2Jmch
• Allele Name: targeted mutation 2, James R Mitchell
• Allele ID: MGI:3696121
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ercc2^tm2Jmch/Ercc2^tm2Jmch	involves: 129P2/OlaHsd * C57BL/6	MGI:3696348
ht2	Ercc2^tm2(ERCC2)Jhjh/Ercc2^tm2Jmch	involves: 129P2/OlaHsd * C57BL/6	MGI:3696349

Genotype
MGI:3696348

hm1

• Allelic Composition: Ercc2^tm2Jmch/Ercc2^tm2Jmch
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality before implantation, complete penetrance ( J:116054 )

• no homozygous embryos are found at E3.5

Genotype
MGI:3696349

ht2

• Allelic Composition: Ercc2^{tm2(ERCC2)Jhjh}/Ercc2^tm2Jmch
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Cutaneous phenotypes of Ercc2^{tm2(ERCC2)Jhjh}/Ercc2^{tm2(ERCC2)Jhjh} and Ercc2^{tm2(ERCC2)Jhjh}/Ercc2^tm2Jmch mice

mortality/aging

mortality/aging ( J:116054 )

N • normal lifespan unlike Ercc2^{tm2(ERCC2)Jhjh} homozygotes

growth/size/body

growth/size/body region phenotype ( J:116054 )

N • full rescue of age-related cachexia that is seen in Ercc2^{tm2(ERCC2)Jhjh} homozygotes

postnatal growth retardation ( J:116054 )

• partial rescue of developmental delay compared to Ercc2^{tm2(ERCC2)Jhjh} homozygotes

hematopoietic system

anemia ( J:116054 )

• partially rescued compared to Ercc2^{tm2(ERCC2)Jhjh} homozygotes

skeleton

skeleton phenotype ( J:116054 )

N • mice do not develop osteoporosis or kyphosis any earlier than wild-type mice

cellular

decreased cellular sensitivity to ultraviolet irradiation ( J:116054 )

• UV sensitivity is less than in Ercc2^{tm2(ERCC2)Jhjh} homozygotes

integument

integument phenotype ( J:116054 )

N • absence of acanthosis, hyperkeratosis, and granular layer and sebacious gland hyperplasia

focal dorsal hair loss ( J:116054 )

• only seen during the first hair cycle and only locally on the back

brittle hair ( J:116054 )

• less severe than in Ercc2^{tm2(ERCC2)Jhjh} homozygotes

• only a very low frequency of broken hairs