Phenotypes associated with this allele

• Allele Symbol: Tg(ACTB-DDAH1)1Jpck
• Allele Name: transgene insertion 1, John P Cooke
• Allele ID: MGI:3696379
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(ACTB-DDAH1)1Jpck/0	involves: C57BL/6J	MGI:3696413

Genotype
MGI:3696413

tg1

• Allelic Composition: Tg(ACTB-DDAH1)1Jpck/0
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal cardiovascular system physiology ( J:104238 )

decreased cardiac stroke volume ( J:104238 )

• stroke volume is reduced by ~10% in transgenic mice

decreased systemic vascular resistance ( J:104238 )

• systemic vascular resistance is reduced by ~10% compared to controls

increased heart rate ( J:104238 )

• transgenic mice display ~10% increase in heart rate

decreased systemic arterial blood pressure ( J:104238 )

• mean arterial pressure is reduced by ~10% compared to controls

decreased systemic arterial systolic blood pressure ( J:104238 )

• pressure is lower (105.9 mm Hg) than in age- and weight-matched conscious controls (112.7 mm Hg)

• systolic pressure difference is greater (13 mm Hg) in anesthetized transgenics (76 mm Hg) compared to controls (89 mm Hg)

homeostasis/metabolism

abnormal enzyme/coenzyme level ( J:104238 )

• nitric oxide synthase (NOS) activity is significantly increased in transgenic skeletal muscle; cardiac tissue homogenates have higher NOS activity

abnormal nitric oxide homeostasis ( J:104238 )

• transgenic skeletal muscle homogenates have greater NOS activity