Analysis Tools
nervous system
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• 14-15 month old mutants backcrossed 5- or 10 generations tend to have higher accumulation of amyloid compared to Tg(APP695)3Dbo at that age
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behavior/neurological
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• as females age (13-14 months of age), significant difference compared to female controls is observed in trials with longest (<60 minute) delays
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• 12-13 month old males and females backcrossed 5-7 generations show poorer performance in probe trials in the Morris water maze; females spent less time in correct quadrant until fourth consectutive session
• upon repeat testing of the same females one month later, difference between mutants and controls is more robust; repeated testing had no effect on performance
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• at 12-13 months, females backcrossed 5-7 generations are less active in visiting open arms in plus maze; combined with reduced rearing reactions, females may have higher anxiety levels
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• in radial maze testing, male mutants backcrossed 5-7 generations show high motor reactivity compared to females or control animals, and entered the closest arm of the maze which prevented them from learning the task
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• at 12-13 months, mice backcrossed 5-7 generations show fewer rearing reactions compared to nontransgenic littermates
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• at 12-13 months, males backcrossed 5-7 generations are less active than controls in inner cells of open field
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homeostasis/metabolism
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• 14-15 month old mutants backcrossed 5- or 10 generations tend to have higher accumulation of amyloid compared to Tg(APP695)3Dbo at that age
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| Alzheimer's disease | DOID:10652 | J:109847 | ||
