About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(tetO-Hand1)1Prri
transgene insertion 1, Paul R Riley
MGI:3696547
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Hand1tm1(tTA)Prri/Hand1+
Tg(tetO-Hand1)1Prri/0
involves: 129/Sv * C57BL/6 MGI:3696548


Genotype
MGI:3696548
cx1
Allelic
Composition
Hand1tm1(tTA)Prri/Hand1+
Tg(tetO-Hand1)1Prri/0
Genetic
Background
involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hand1tm1(tTA)Prri mutation (0 available); any Hand1 mutation (15 available)
Tg(tetO-Hand1)1Prri mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• severely affected mutants do not survive beyond E10.5, however moderately and mildly affected mutants recover from the phenotype, such that they survive to birth

cardiovascular system
• severely affected mutants display elevated myocyte density and cellular hypertrophy in the left ventricle
• the outflow tract is elongated distally and physically displaced from the inflow region
• exhibit elevated proliferation of cardiomyocytes in the distal outflow tract
• exhibit variable penetrance of cardiac development abnormalities: those mildly or moderately affected mutants recover from the phenotypes, such that by E12.5-14.5, heart development appears normal, while severely affected mutants die by E10.5
• as early as E8, exhibit extension of looping
• at E9.5, hearts do not show a defect in the initiation and onset of looping as hearts loop to the right, however looping is abnormal, with a significant overextension of the heart tube
• as early as E8, exhibit expansion of the primary heart tube
• heart tube is displaced both ventrally away from the body and laterally
• exhibit defective left ventricle development, impaired left ventricle differentiation and expansion leading to severe necrosis
• in moderately affected mutants, the presumptive left ventricle is reduced in size but undergoes expansion
• in severely affected mutants, ventricular expansion fails and is associated with an almost complete absence of chamber lumen
• exhibit elevated proliferation of cardiomyocytes in the distal outflow tract

muscle
• severely affected mutants display elevated myocyte density and cellular hypertrophy in the left ventricle
• exhibit elevated proliferation of cardiomyocytes in the distal outflow tract

cellular
• exhibit elevated proliferation of cardiomyocytes in the distal outflow tract





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
11/12/2024
MGI 6.24
The Jackson Laboratory