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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(tetO-Hand1)1Prri
transgene insertion 1, Paul R Riley
MGI:3696547
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Hand1tm1(tTA)Prri/Hand1+
Tg(tetO-Hand1)1Prri/0
involves: 129/Sv * C57BL/6 MGI:3696548


Genotype
MGI:3696548
cx1
Allelic
Composition
Hand1tm1(tTA)Prri/Hand1+
Tg(tetO-Hand1)1Prri/0
Genetic
Background
involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hand1tm1(tTA)Prri mutation (0 available); any Hand1 mutation (15 available)
Tg(tetO-Hand1)1Prri mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• severely affected mutants do not survive beyond E10.5, however moderately and mildly affected mutants recover from the phenotype, such that they survive to birth

cardiovascular system
• severely affected mutants display elevated myocyte density and cellular hypertrophy in the left ventricle
• exhibit elevated proliferation of cardiomyocytes in the distal outflow tract
• the outflow tract is elongated distally and physically displaced from the inflow region
• exhibit variable penetrance of cardiac development abnormalities: those mildly or moderately affected mutants recover from the phenotypes, such that by E12.5-14.5, heart development appears normal, while severely affected mutants die by E10.5
• as early as E8, exhibit extension of looping
• at E9.5, hearts do not show a defect in the initiation and onset of looping as hearts loop to the right, however looping is abnormal, with a significant overextension of the heart tube
• as early as E8, exhibit expansion of the primary heart tube
• heart tube is displaced both ventrally away from the body and laterally
• exhibit defective left ventricle development, impaired left ventricle differentiation and expansion leading to severe necrosis
• in moderately affected mutants, the presumptive left ventricle is reduced in size but undergoes expansion
• in severely affected mutants, ventricular expansion fails and is associated with an almost complete absence of chamber lumen
• exhibit elevated proliferation of cardiomyocytes in the distal outflow tract

muscle
• severely affected mutants display elevated myocyte density and cellular hypertrophy in the left ventricle
• exhibit elevated proliferation of cardiomyocytes in the distal outflow tract

cellular
• exhibit elevated proliferation of cardiomyocytes in the distal outflow tract





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory