Phenotypes associated with this allele

• Allele Symbol: Krt14^{tm1(Krt10)Pko}
• Allele Name: targeted mutation 1, Peter J Koch
• Allele ID: MGI:3696658
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Krt14^tm1(Krt10)Pko/Krt14^tm1(Krt10)Pko	B6.Cg-Krt14^tm1(Krt10)Pko	MGI:3697588

Genotype
MGI:3697588

hm1

• Allelic Composition: Krt14^{tm1(Krt10)Pko}/Krt14^{tm1(Krt10)Pko}
• Genetic Background: B6.Cg-Krt14^{tm1(Krt10)Pko}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased skin papilloma incidence ( J:117347 )

• when treated with DMBA/TPA to chemically induce skin carcinogenesis, mutants develop skin papillomas earlier than wild-type controls; after 10 weeks of TPA treatment, >50% of mice have at least one papilloma compared to 5% of control mice

• at end of TPA treatment, all mutants developed tumors compared to 85% of controls

• mutants carry an average of 2-3 times as many tumors as control; as a result, 2-3 times as many mutants develop squamous cell carcinomas after end of TPA treatment

integument

abnormal keratinocyte apoptosis ( J:117347 )

• after treatment with UV-B, mutants show 27% more apoptotic keratinocytes in the interfollicular epidermis than controls

• cultured keratinocytes from newborns show significantly reduced apoptotic response to TNF alpha compared to controls

abnormal epidermal layer morphology ( J:117347 )

• animals >18 months develop chronic skin erosions (loss of epidermis)

abnormal epidermis stratum corneum morphology ( J:117347 )

• by 12 months of age, mutants develop lesions of the stratum corneum

increased skin papilloma incidence ( J:117347 )

• when treated with DMBA/TPA to chemically induce skin carcinogenesis, mutants develop skin papillomas earlier than wild-type controls; after 10 weeks of TPA treatment, >50% of mice have at least one papilloma compared to 5% of control mice

• at end of TPA treatment, all mutants developed tumors compared to 85% of controls

• mutants carry an average of 2-3 times as many tumors as control; as a result, 2-3 times as many mutants develop squamous cell carcinomas after end of TPA treatment

cellular

abnormal keratinocyte apoptosis ( J:117347 )

• after treatment with UV-B, mutants show 27% more apoptotic keratinocytes in the interfollicular epidermis than controls

• cultured keratinocytes from newborns show significantly reduced apoptotic response to TNF alpha compared to controls