Phenotypes associated with this allele

• Allele Symbol: Rpl29^tm1Udel
• Allele Name: targeted mutation 1, Daniel D Carson
• Allele ID: MGI:3696667
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rpl29^tm1Udel/Rpl29^tm1Udel	129S6/SvEvTac-Rpl29^tm1Udel	MGI:3697613
hm2	Rpl29^tm1Udel/Rpl29^tm1Udel	involves: 129S6/SvEvTac * C57BL/6J	MGI:3697612

Genotype
MGI:3697613

hm1

• Allelic Composition: Rpl29^tm1Udel/Rpl29^tm1Udel
• Genetic Background: 129S6/SvEvTac-Rpl29^tm1Udel

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality, incomplete penetrance ( J:117229 )

• fewer than the expected numbers of homozygotes are seen at weaning (13% instead of the expected 25%)

growth/size/body

embryonic growth retardation ( J:117229 )

• starting around E14.5, fetuses and placenta show a global growth delay, including delayed digit and incisor formation

decreased body weight ( J:117229 )

• from birth to weaning, do not gain weight as rapidly as controls so that at weaning are 50% smaller than wild-type

• at 6 weeks of age, remain 30% smaller than wild-type and in adulthood, weigh about 25% less

postnatal growth retardation ( J:117229 )

• postnatal development, including fur growth, eyelid opening, and incisor eruption are routinely delayed

embryo

embryonic growth retardation ( J:117229 )

• starting around E14.5, fetuses and placenta show a global growth delay, including delayed digit and incisor formation

skeleton

delayed bone ossification ( J:117229 )

• exhibit delayed ossification that is particularly visible in phalangeal, metatarsal, talus, and calcaneous bones of the foot

cellular

abnormal cell cycle ( J:117229 )

• primary MEFs remain longer in G1

decreased fibroblast proliferation ( J:117229 )

• isolated primary MEFs proliferate about 45% slower than wild-type

Genotype
MGI:3697612

hm2

• Allelic Composition: Rpl29^tm1Udel/Rpl29^tm1Udel
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

mortality/aging

preweaning lethality, incomplete penetrance ( J:117229 )

• approximately 40% fewer than the expected numbers of homozygotes are seen at weaning (15% instead of the expected 25%)

growth/size/body

embryonic growth retardation ( J:117229 )

• starting around E14.5, fetuses and placenta show a global growth delay, including delayed digit and incisor formation

decreased body weight ( J:117229 )

• from birth to weaning, do not gain weight as rapidly as controls so that at weaning are about 30% smaller than wild-type and at 6 weeks of age, remain 15% smaller than wild-type

postnatal growth retardation ( J:117229 )

• postnatal development, including fur growth, eyelid opening, and incisor eruption are routinely delayed by 3-4 days in pups; those surviving past these stages remain delayed in development and are weaned about a week later than controls

embryo

embryonic growth retardation ( J:117229 )

• starting around E14.5, fetuses and placenta show a global growth delay, including delayed digit and incisor formation

reproductive system

delayed sexual maturation ( J:117229 )

• homozygotes still alive the first week after delivery usually survive and eventually reach sexual maturity but with a considerable delay of about a month