Phenotypes associated with this allele

• Allele Symbol: Esr1^tm1Gsc
• Allele Name: targeted mutation 1, Gunther Schutz
• Allele ID: MGI:3696669
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Esr1^tm1Gsc/Esr1^tm1Gsc Tg(Camk2a-cre)2Gsc/0	involves: 129P2/OlaHsd * C57BL/6 * FVB/N	MGI:3698024

Genotype
MGI:3698024

cn1

• Allelic Composition: Esr1^tm1Gsc/Esr1^tm1Gsc; Tg(Camk2a-cre)2Gsc/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

abnormal ovary morphology ( J:117231 )

♀

absent corpus luteum ( J:117231 )

♀

increased tertiary ovarian follicle number ( J:117231 )

♀ • contain a large number of antral follicles

abnormal theca cell layer morphology ( J:117231 )

♀ • in the ovarian hilus, theca cells appear hypertrophic and luteinized

abnormal endometrium morphology ( J:117231 )

♀ • the endometrial stroma appears condensed and shows granulocyte infiltration

absent endometrial glands ( J:117231 )

♀ • the endometrium lacks all glandular structures

endometrium atrophy ( J:117231 )

♀ • the endometrium is severely atrophic

dilated uterus ( J:117231 )

♀ • at 5 - 6 weeks of age the uterus is grossly enlarged and filled with fluid

female infertility ( J:117231 )

♀

homeostasis/metabolism

abnormal luteinizing hormone level ( J:117231 )

• ovarectomized, estrogen-treated mice fail to display a luteinizing hormone surge

• however, basal luteinizing hormone levels are similar to wild-type

nervous system

nervous system phenotype ( J:117231 )

N • distribution and number of gonadotropin-releasing hormone neurons are similar to wild-type

endocrine/exocrine glands

absent endometrial glands ( J:117231 )

♀ • the endometrium lacks all glandular structures

abnormal ovary morphology ( J:117231 )

♀

absent corpus luteum ( J:117231 )

♀

increased tertiary ovarian follicle number ( J:117231 )

♀ • contain a large number of antral follicles

abnormal theca cell layer morphology ( J:117231 )

♀ • in the ovarian hilus, theca cells appear hypertrophic and luteinized