Phenotypes associated with this allele

• Allele Symbol: Atf2^{Tg(Gzma-Klra1)7Wum}
• Allele Name: transgene insertion 7, Wayne M Yokoyama
• Allele ID: MGI:3696689
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Atf2^Tg(Gzma-Klra1)7Wum/Atf2^+	involves: C57BL/6	MGI:3813926

Genotype
MGI:3813926

ht1

• Allelic Composition: Atf2^{Tg(Gzma-Klra1)7Wum}/Atf2⁺
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:61178 )

N • mice exhibit normal numbers and functions of lymphocytes other than NK cells

N • despite the reduction in NK cells and function, mice exhibit a normal generalized Shwartzman reaction and normal antibody response to TI type 2 antigen exposure

decreased NK cell number ( J:61178 )

• mice exhibit a reduction in the number of NK1.1+ CD3- spleen cells compared to in wild-type mice

• NK1.1+ CD3- cells are virtually absent from the peripheral blood

decreased NK T cell number ( J:61178 )

• slight decrease in the spleen

abnormal NK cell physiology ( J:61178 )

• unlike in wild-type mice, splenocytes lack natural killing activity towards YAC-1

• mice fail to clear injected tumor cells as do wild-type mice

decreased circulating interferon-gamma level ( J:61178 )

• following injection with LPS, serum levels of IFN-gamma are lower than in similarly treated wild-type mice

• however, mice produce normal levels of IFN-gamma in response to exposure to IL-12

neoplasm

increased metastatic potential ( J:61178 )

• when injected with B16 tumor cells, mice exhibit a greater than 60-fold higher number of lung metastases compared to in similarly treated wild-type mice

• however, the number of liver metastases is normal following injection with B16 tumor cells

cardiovascular system

abnormal artery development ( J:134875 )

• mice exhibit impaired arteriogenesis following occlusion compared to in similarly treated wild-type mice

homeostasis/metabolism

decreased circulating interferon-gamma level ( J:61178 )

• following injection with LPS, serum levels of IFN-gamma are lower than in similarly treated wild-type mice

• however, mice produce normal levels of IFN-gamma in response to exposure to IL-12

hematopoietic system

decreased NK cell number ( J:61178 )

• mice exhibit a reduction in the number of NK1.1+ CD3- spleen cells compared to in wild-type mice

• NK1.1+ CD3- cells are virtually absent from the peripheral blood

decreased NK T cell number ( J:61178 )

• slight decrease in the spleen

abnormal NK cell physiology ( J:61178 )

• unlike in wild-type mice, splenocytes lack natural killing activity towards YAC-1

• mice fail to clear injected tumor cells as do wild-type mice