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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Foxp3tm1Tch
targeted mutation 1, Talal A Chatila
MGI:3696705
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Foxp3tm1Tch/Foxp3+ C.129X1-Foxp3tm1Tch MGI:3697515
cx2
 		Foxp3tm1Tch/Y
Stat6tm1Gru/Stat6tm1Gru 		C.129-Stat6tm1Gru Foxp3tm1Tch MGI:3697518
ot3
 		Foxp3tm1Tch/Y B6.129X1-Foxp3tm1Tch MGI:3697517
ot4
 		Foxp3tm1Tch/Y C.129X1-Foxp3tm1Tch MGI:3697516


Genotype
MGI:3697515
ht1
Allelic
Composition		 Foxp3tm1Tch/Foxp3+
Genetic
Background		 C.129X1-Foxp3tm1Tch
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxp3tm1Tch mutation (2 available); any Foxp3 mutation (58 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:117165 )
• viable and fertile with no signs of lymphoproliferative disorders




Genotype
MGI:3697518
cx2
Allelic
Composition		 Foxp3tm1Tch/Y
Stat6tm1Gru/Stat6tm1Gru
Genetic
Background		 C.129-Stat6tm1Gru Foxp3tm1Tch
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxp3tm1Tch mutation (2 available); any Foxp3 mutation (58 available)
Stat6tm1Gru mutation (4 available); any Stat6 mutation (53 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
lethality at weaning, complete penetrance ( J:117165 )
• median survival is increased to 23 days; however the upper limit of survival span is not increased compared to Foxp3 single hemizygotes

immune system
immune system phenotype ( J:117165 )
N
• normalized levels of IgE
increased eosinophil cell number ( J:117165 )
• increased compared to wild-type but decreased compared to Foxp3 single hemizygotes
abnormal cytokine secretion ( J:117165 )
• profoundly impaired production of Th2 cytokines and enhanced production of Th1 cytokines

respiratory system
respiratory system phenotype ( J:117165 )
N
• goblet cell metaplasia in the lungs is absent

hematopoietic system
increased eosinophil cell number ( J:117165 )
• increased compared to wild-type but decreased compared to Foxp3 single hemizygotes

homeostasis/metabolism




Genotype
MGI:3697517
ot3
Allelic
Composition		 Foxp3tm1Tch/Y
Genetic
Background		 B6.129X1-Foxp3tm1Tch
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxp3tm1Tch mutation (2 available); any Foxp3 mutation (58 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, complete penetrance ( J:117165 )
• Background Sensitivity: survival is longer than in mice on a BALB/c background

immune system
increased eosinophil cell number ( J:117165 )
• marked blood eosinophilia
increased IgE level ( J:117165 )
• hyperimmunoglobulinemia E
• at 23 to 30 days of age, IgE levels are increased by about 4 orders of magnitude compared to littermate controls
abnormal inflammatory response ( J:117165 )
• multisystem lymphoproliferative and myeloproliferative disease similar to mice on a BALB/c background
respiratory system inflammation ( J:117165 )
• allergic airway inflammation found at 2 weeks of age
• inflammation includes peribronchial infiltrates, goblet cell metaplasia, and mucus impaction
dermatitis ( J:117165 )
• prominent

hematopoietic system
increased eosinophil cell number ( J:117165 )
• marked blood eosinophilia
increased IgE level ( J:117165 )
• hyperimmunoglobulinemia E
• at 23 to 30 days of age, IgE levels are increased by about 4 orders of magnitude compared to littermate controls

respiratory system
respiratory system inflammation ( J:117165 )
• allergic airway inflammation found at 2 weeks of age
• inflammation includes peribronchial infiltrates, goblet cell metaplasia, and mucus impaction

integument
dermatitis ( J:117165 )
• prominent




Genotype
MGI:3697516
ot4
Allelic
Composition		 Foxp3tm1Tch/Y
Genetic
Background		 C.129X1-Foxp3tm1Tch
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxp3tm1Tch mutation (2 available); any Foxp3 mutation (58 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, complete penetrance ( J:117165 , J:120636 )
• median survival is 16.5 days (J:117165)
• Background Sensitivity: survival is shorter than in mice on a C57BL/6 background (J:117165)
• hemizygous males develop lymphoproliferative disease with median survival of ~15 days of age, similar to Foxp3tm3Tch males (J:120636)

immune system
enlarged spleen ( J:117165 )
• massive splenomegaly at 2 weeks of age
absent regulatory T cells ( J:117165 )
• absence of CD4+ CD25+ regulatory T cells
increased eosinophil cell number ( J:117165 )
• marked blood eosinophilia
increased CD4-positive, alpha-beta T cell number ( J:117165 )
• marked expansion of CD4+ cell populations
increased CD8-positive, alpha-beta T cell number ( J:117165 )
• marked expansion of CD8+ cell populations
increased activated T cell number ( J:117165 )
• significant proportion of CD4+ and CD8+ cell populations are activated
abnormal lymphocyte physiology ( J:117165 )
• at 2 weeks of age mice display an intense lymphoproliferative and myeloproliferative disorder
increased IgE level ( J:117165 )
• hyperimmunoglobulinemia E
increased IgG1 level ( J:117165 )
• striking increase in IgG1
increased circulating interleukin-10 level ( J:117165 )
• elevated levels of IL-10
increased circulating interleukin-4 level ( J:117165 )
• elevated levels of IL-4
increased circulating interleukin-5 level ( J:117165 )
• elevated levels of IL-5
increased circulating interleukin-6 level ( J:117165 )
• elevated levels of IL-6
abnormal chemokine level ( J:117165 )
• elevated levels of chemotactic factor monocyte chemotactic protein 1
abnormal cytokine secretion ( J:117165 )
• nonselective dysregulated production of both Th1 and Th2 cytokines
abnormal inflammatory response ( J:117165 )
• mixed inflammatory infiltrate containing lymphocytes, neutrophils, monocytes, and eosinophils is found in the liver, stomach, pancreas, and skin
• an eosinophilic and neutrophilic infiltration is found in the gastrointestinal tract
respiratory system inflammation ( J:117165 )
• allergic airway inflammation found at 2 weeks of age
• inflammation includes peribronchial infiltrates, goblet cell metaplasia, and mucus impaction
dermatitis ( J:117165 )
• prominent

hematopoietic system
enlarged spleen ( J:117165 )
• massive splenomegaly at 2 weeks of age
absent regulatory T cells ( J:117165 )
• absence of CD4+ CD25+ regulatory T cells
increased eosinophil cell number ( J:117165 )
• marked blood eosinophilia
increased CD4-positive, alpha-beta T cell number ( J:117165 )
• marked expansion of CD4+ cell populations
increased CD8-positive, alpha-beta T cell number ( J:117165 )
• marked expansion of CD8+ cell populations
increased activated T cell number ( J:117165 )
• significant proportion of CD4+ and CD8+ cell populations are activated
abnormal lymphocyte physiology ( J:117165 )
• at 2 weeks of age mice display an intense lymphoproliferative and myeloproliferative disorder
increased IgE level ( J:117165 )
• hyperimmunoglobulinemia E
increased IgG1 level ( J:117165 )
• striking increase in IgG1

digestive/alimentary system
crypts of Lieberkuhn abscesses ( J:117165 )
• seen at 2 weeks of age

respiratory system
respiratory system inflammation ( J:117165 )
• allergic airway inflammation found at 2 weeks of age
• inflammation includes peribronchial infiltrates, goblet cell metaplasia, and mucus impaction
abnormal respiratory mucosa goblet cell morphology ( J:117165 )
• goblet cell metaplasia in the lungs

endocrine/exocrine glands
crypts of Lieberkuhn abscesses ( J:117165 )
• seen at 2 weeks of age

homeostasis/metabolism
increased circulating interleukin-10 level ( J:117165 )
• elevated levels of IL-10
increased circulating interleukin-4 level ( J:117165 )
• elevated levels of IL-4
increased circulating interleukin-5 level ( J:117165 )
• elevated levels of IL-5
increased circulating interleukin-6 level ( J:117165 )
• elevated levels of IL-6
abnormal chemokine level ( J:117165 )
• elevated levels of chemotactic factor monocyte chemotactic protein 1

integument
dermatitis ( J:117165 )
• prominent

growth/size/body
enlarged spleen ( J:117165 )
• massive splenomegaly at 2 weeks of age




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory