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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Myh6-Camta2)1Eno
transgene insertion 1, Eric N Olson
MGI:3696706
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Hdac5tm1Eno/Hdac5tm1Eno
Tg(Myh6-Camta2)1Eno/0 		involves: 129S2/SvPas MGI:3696715
tg2
 		Tg(Myh6-Camta2)1Eno/0 Not Specified MGI:3696709


Genotype
MGI:3696715
cx1
Allelic
Composition		 Hdac5tm1Eno/Hdac5tm1Eno
Tg(Myh6-Camta2)1Eno/0
Genetic
Background		 involves: 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hdac5tm1Eno mutation (0 available); any Hdac5 mutation (57 available)
Tg(Myh6-Camta2)1Eno mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
cardiac hypertrophy ( J:115868 )
• exhibit even more enhanced cardiac hypertrophy (twice the amount) than single transgenic Tg(Myh6-Camta2)1Eno mice

growth/size/body
cardiac hypertrophy ( J:115868 )
• exhibit even more enhanced cardiac hypertrophy (twice the amount) than single transgenic Tg(Myh6-Camta2)1Eno mice




Genotype
MGI:3696709
tg2
Allelic
Composition		 Tg(Myh6-Camta2)1Eno/0
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:115868 )
• all die by 12 weeks of age due to heart failure

cardiovascular system
cardiac hypertrophy ( J:115868 )
• hearts show extensive myocyte hypertrophy; hypertrophy worsens between 4 and 8 weeks of age
dilated cardiomyopathy ( J:115868 )
• by 9 weeks of age, hypertrophy progresses to dilated cardiomyopathy
congestive heart failure ( J:115868 )
• by 9 weeks of age, hypertrophy progresses to heart failure

muscle
dilated cardiomyopathy ( J:115868 )
• by 9 weeks of age, hypertrophy progresses to dilated cardiomyopathy

growth/size/body
enlarged heart ( J:115868 )
cardiac hypertrophy ( J:115868 )
• hearts show extensive myocyte hypertrophy; hypertrophy worsens between 4 and 8 weeks of age




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory