Phenotypes associated with this allele

• Allele Symbol: Zglp1^tm1Eem
• Allele Name: targeted mutation 1, Edward E Morrisey
• Allele ID: MGI:3696745
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Zglp1^tm1Eem/Zglp1^tm1Eem	involves: 129S1/Sv * 129X1/SvJ	MGI:3698299

Genotype
MGI:3698299

hm1

• Allelic Composition: Zglp1^tm1Eem/Zglp1^tm1Eem
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

decreased male germ cell number ( J:116977 )

♂ • loss of early spermatocytes contributes to reduced gonad volume

increased testis apoptosis ( J:116977 )

• at 2 months of age, TUNEL assays indicate a significant increase in apoptosis, primarily in the outer layers of the seminiferous tubules where early spermatocytes are differentiating, unlike in wild-type testes

abnormal ovarian follicle morphology ( J:116977 )

♀

decreased mature ovarian follicle number ( J:116977 )

♀

absent ovarian follicles ( J:116977 )

♀

abnormal ovarian folliculogenesis ( J:116977 )

♀

absent mature ovarian follicles ( J:116977 )

♀

small ovary ( J:116977 )

♀ • at 1 month of age ovaries are smaller than ovaries of normal siblings

♀ • by 6 months of age, ovary size normalizes as somatic cells have replaced volume lost by depletion of germ cells

small testis ( J:116977 )

♂ • by 5 weeks of age testes are smaller compared to testes of normal siblings

abnormal spermatogenesis ( J:116977 )

♂

oligozoospermia ( J:116977 )

♂ • revealed at 6 months of age by TEM

abnormal spermatogonia proliferation ( J:116977 )

♂ • TUNEL assays detected a significant increase in apoptosis in outer layers of seminiferous tubules

♂ • from 1-6 months of age few mature sperm are found

infertility ( J:116977 )

female infertility ( J:116977 )

♀

male infertility ( J:116977 )

♂

endocrine/exocrine glands

increased testis apoptosis ( J:116977 )

• at 2 months of age, TUNEL assays indicate a significant increase in apoptosis, primarily in the outer layers of the seminiferous tubules where early spermatocytes are differentiating, unlike in wild-type testes

abnormal ovarian follicle morphology ( J:116977 )

♀

decreased mature ovarian follicle number ( J:116977 )

♀

absent ovarian follicles ( J:116977 )

♀

abnormal ovarian folliculogenesis ( J:116977 )

♀

absent mature ovarian follicles ( J:116977 )

♀

small ovary ( J:116977 )

♀ • at 1 month of age ovaries are smaller than ovaries of normal siblings

♀ • by 6 months of age, ovary size normalizes as somatic cells have replaced volume lost by depletion of germ cells

small testis ( J:116977 )

♂ • by 5 weeks of age testes are smaller compared to testes of normal siblings

cellular

decreased male germ cell number ( J:116977 )

♂ • loss of early spermatocytes contributes to reduced gonad volume

oligozoospermia ( J:116977 )

♂ • revealed at 6 months of age by TEM

increased testis apoptosis ( J:116977 )

• at 2 months of age, TUNEL assays indicate a significant increase in apoptosis, primarily in the outer layers of the seminiferous tubules where early spermatocytes are differentiating, unlike in wild-type testes

abnormal spermatogonia proliferation ( J:116977 )

♂ • TUNEL assays detected a significant increase in apoptosis in outer layers of seminiferous tubules

♂ • from 1-6 months of age few mature sperm are found

homeostasis/metabolism

increased circulating follicle stimulating hormone level ( J:116977 )

♀ • serum FSH levels are signficantly higher compared to levels found for normal

♀ • in contrast, serum estradiol levels were identical at 1 and 6 months of age

increased circulating luteinizing hormone level ( J:116977 )

• serum LH levels are signficantly higher compared to levels found for normal