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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Sfrp5tm1Shwl
targeted mutation 1, William Shawlot
MGI:3696766
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Sfrp5tm1Shwl/Sfrp5tm1Shwl either: 129S-Sfrp5tm1Shwl or B6.129S7-Sfrp5tm1Shwl MGI:3697479
hm2
 		Sfrp5tm1Shwl/Sfrp5tm1Shwl involves: 129S7/SvEvBrd * CD-1 MGI:3697478
cx3
 		Dkk1tm1Lmgd/Dkk1tm1Lmgd
Sfrp5tm1Shwl/Sfrp5tm1Shwl 		involves: 129 * CD-1 MGI:3697480


Genotype
MGI:3697479
hm1
Allelic
Composition		 Sfrp5tm1Shwl/Sfrp5tm1Shwl
Genetic
Background		 either: 129S-Sfrp5tm1Shwl or B6.129S7-Sfrp5tm1Shwl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sfrp5tm1Shwl mutation (0 available); any Sfrp5 mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:117057 )
• viable and fertile




Genotype
MGI:3697478
hm2
Allelic
Composition		 Sfrp5tm1Shwl/Sfrp5tm1Shwl
Genetic
Background		 involves: 129S7/SvEvBrd * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sfrp5tm1Shwl mutation (0 available); any Sfrp5 mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:117057 )
• viable and fertile with normal forgut morphogenesis, liver bud development, axis formation, anterior visceral endoderm development, and primitive streak formation




Genotype
MGI:3697480
cx3
Allelic
Composition		 Dkk1tm1Lmgd/Dkk1tm1Lmgd
Sfrp5tm1Shwl/Sfrp5tm1Shwl
Genetic
Background		 involves: 129 * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dkk1tm1Lmgd mutation (0 available); any Dkk1 mutation (18 available)
Sfrp5tm1Shwl mutation (0 available); any Sfrp5 mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
perinatal lethality, complete penetrance ( J:117057 )
• no viable double homozygotes are found

embryo
embryo phenotype ( J:117057 )
N
• location of the anterior visceral endoderm and primitive streak morphology are similar to controls

growth/size/body
abnormal anterior head development ( J:117057 )
• at E17.5 9 of 18 mice lack anterior head structures
• this is not significantly different from Dkk1 single homozygotes on the same genetic background




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory