Phenotypes associated with this allele

• Allele Symbol: Mcm4^chaos3
• Allele Name: chromosomal aberration occurring spontaneously 3
• Allele ID: MGI:3696791
• Summary: 14 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mcm4^chaos3/Mcm4^chaos3	C3.B6-Mcm4^chaos3	MGI:3696835
hm2	Mcm4^chaos3/Mcm4^chaos3	involves: C3HeB/FeJ * C57BL/6J	MGI:3696824
hm3	Mcm4^chaos3/Mcm4^chaos3	involves: C57BL/6J	MGI:3696823
ht4	Mcm4^chaos3/Mcm4^+	involves: C57BL/6J	MGI:3696822
ht5	Mcm4^chaos3/Mcm4^Gt(RRE056)Byg	B6.Cg-Mcm4^chaos3 Mcm4^Gt(RRE056)Byg	MGI:3696836
ht6	Mcm4^chaos3/Mcm4^Gt(RRE056)Byg	involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J	MGI:3696840
ht7	Mcm4^chaos3/Mcm4^Sdla	involves: C57BL/6 * C57BL/6J	MGI:5473714
cx8	Mcm2^Gt(AB0178)Wtsi/Mcm2^+ Mcm3^Gt(RRR002)Byg/Mcm3^+ Mcm4^chaos3/Mcm4^chaos3	involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J	MGI:4838110
cx9	Mcm2^Gt(AB0178)Wtsi/Mcm2^+ Mcm4^chaos3/Mcm4^chaos3	involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J	MGI:4838107
cx10	Mcm3^Gt(RRR002)Byg/Mcm3^+ Mcm4^chaos3/Mcm4^Gt(RRE056)Byg	involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J	MGI:4838113
cx11	Mcm3^Gt(RRR002)Byg/Mcm3^+ Mcm4^chaos3/Mcm4^chaos3 Mcm6^Gt(YHD248)Byg/Mcm6^+	involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J	MGI:4838114
cx12	Mcm3^Gt(RRR002)Byg/Mcm3^+ Mcm4^chaos3/Mcm4^chaos3	involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J	MGI:4838115
cx13	Mcm4^chaos3/Mcm4^chaos3 Mcm6^Gt(YHD248)Byg/Mcm6^+	involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J	MGI:4838116
cx14	Mcm4^chaos3/Mcm4^chaos3 Mcm7^Gt(YTA285)Byg/Mcm7^+	involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J	MGI:4838117

Genotype
MGI:3696835

hm1

• Allelic Composition: Mcm4^chaos3/Mcm4^chaos3
• Genetic Background: C3.B6-Mcm4^chaos3

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased mammary gland tumor incidence ( J:117494 )

• females (majority are virgin) show a high susceptibility to development of mammary tumors

increased mammary adenocarcinoma incidence ( J:117494 )

• 13/16 females develop mammary tumors with a latency of 12 months; five animals had more than one tumor

• 9/18 tumors were in thoracic mammary gland and 7/18 were in cervical mammary gland

increased hepatocellular carcinoma incidence ( J:117494 )

• 1 female developed a hepatocellular carcinoma

increased lung adenocarcinoma incidence ( J:117494 )

• 2 mammary tumors metastasized to lung

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:117494 )

• females (majority are virgin) show a high susceptibility to development of mammary tumors

increased mammary adenocarcinoma incidence ( J:117494 )

• 13/16 females develop mammary tumors with a latency of 12 months; five animals had more than one tumor

• 9/18 tumors were in thoracic mammary gland and 7/18 were in cervical mammary gland

respiratory system

increased lung adenocarcinoma incidence ( J:117494 )

• 2 mammary tumors metastasized to lung

liver/biliary system

increased hepatocellular carcinoma incidence ( J:117494 )

• 1 female developed a hepatocellular carcinoma

integument

increased mammary gland tumor incidence ( J:117494 )

• females (majority are virgin) show a high susceptibility to development of mammary tumors

increased mammary adenocarcinoma incidence ( J:117494 )

• 13/16 females develop mammary tumors with a latency of 12 months; five animals had more than one tumor

• 9/18 tumors were in thoracic mammary gland and 7/18 were in cervical mammary gland

Genotype
MGI:3696824

hm2

• Allelic Composition: Mcm4^chaos3/Mcm4^chaos3
• Genetic Background: involves: C3HeB/FeJ * C57BL/6J

cellular

abnormal cell cycle ( J:117494 )

• there are a lower number of cells in S phase and slightly increased G2/M populations compared to controls

decreased cell proliferation ( J:117494 )

• mouse embryonic fibroblasts (MEFs) show a mild defect in proliferation

Genotype
MGI:3696823

hm3

• Allelic Composition: Mcm4^chaos3/Mcm4^chaos3
• Genetic Background: involves: C57BL/6J

mortality/aging

premature death ( J:165667 )

• mice die sooner than Mcm3^{Gt(RRR002)Byg}/Mcm3⁺ Mcm4^chaos3/Mcm4^chaos3 mice

neoplasm

increased mammary gland tumor incidence ( J:165667 )

• after 12 months of age compared with Mcm3^{Gt(RRR002)Byg}/ Mcm3⁺ Mcm4^chaos3/Mcm4^chaos3 mice

increased lymphoma incidence ( J:165667 )

• unlike Mcm3^{Gt(RRR002)Byg}/Mcm3⁺ Mcm4^chaos3/Mcm4^chaos3 mice

increased T cell derived lymphoma incidence ( J:165667 )

• unlike Mcm3^{Gt(RRR002)Byg}/Mcm3⁺ Mcm4^chaos3/Mcm4^chaos3 mice

hematopoietic system

increased T cell derived lymphoma incidence ( J:165667 )

• unlike Mcm3^{Gt(RRR002)Byg}/Mcm3⁺ Mcm4^chaos3/Mcm4^chaos3 mice

abnormal erythrocyte morphology ( J:117494 , J:165667 )

• >7% of erythrocytes contain micronuclei (J:117494)

• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice (J:165667)

cellular

abnormal cell nucleus morphology ( J:117494 )

• show 20-fold elevated micronucleus frequencies compared to wild-type

chromosomal instability ( J:165667 )

• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice

integument

increased mammary gland tumor incidence ( J:165667 )

• after 12 months of age compared with Mcm3^{Gt(RRR002)Byg}/ Mcm3⁺ Mcm4^chaos3/Mcm4^chaos3 mice

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:165667 )

• unlike Mcm3^{Gt(RRR002)Byg}/Mcm3⁺ Mcm4^chaos3/Mcm4^chaos3 mice

increased mammary gland tumor incidence ( J:165667 )

• after 12 months of age compared with Mcm3^{Gt(RRR002)Byg}/ Mcm3⁺ Mcm4^chaos3/Mcm4^chaos3 mice

immune system

increased T cell derived lymphoma incidence ( J:165667 )

• unlike Mcm3^{Gt(RRR002)Byg}/Mcm3⁺ Mcm4^chaos3/Mcm4^chaos3 mice

Genotype
MGI:3696822

ht4

• Allelic Composition: Mcm4^chaos3/Mcm4⁺
• Genetic Background: involves: C57BL/6J

cellular

abnormal cell nucleus morphology ( J:117494 )

• show 2- to 5-fold elevated micronucleus frequencies compared to wild-type

Genotype
MGI:3696836

ht5

• Allelic Composition: Mcm4^chaos3/Mcm4^{Gt(RRE056)Byg}
• Genetic Background: B6.Cg-Mcm4^chaos3 Mcm4^{Gt(RRE056)Byg}

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:117494 )

• embryos are found until E14.5

• Background Sensitivity: on mixed backgrounds, mutants show extended survival

embryo

embryonic growth retardation ( J:117494 )

• majority are growth retarded

growth/size/body

embryonic growth retardation ( J:117494 )

• majority are growth retarded

cellular

abnormal cell cycle ( J:117494 )

• there are a lower number of cells in S phase and slightly increased G2/M populations compared to controls

decreased fibroblast proliferation ( J:117494 )

• mouse embryonic fibroblasts (MEFs) show a mild defect in proliferation

induced chromosome breakage ( J:117494 )

• MEFs are highly susceptible to aphidicolin-induced chromosome breaks

Genotype
MGI:3696840

ht6

• Allelic Composition: Mcm4^chaos3/Mcm4^{Gt(RRE056)Byg}
• Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J

mortality/aging

perinatal lethality, incomplete penetrance ( J:117494 , J:165667 )

• double mutants are observed at E18.5; a small number survive past birth (J:117494)

• Background Sensitivity: survival is extended compared to B6 congenic background (J:117494)

• fewer than expected mice are alive at birth (J:165667)

postnatal lethality, incomplete penetrance ( J:165667 )

• very few mice are present at weaning

growth/size/body

fetal growth retardation ( J:117494 )

• at E18.5, animals are markedly smaller than control littermates

digestive/alimentary system

abnormal digestive system development ( J:117494 )

• mice surviving to P2 show abnormal development of digestive system; milk spot appears diffuse and spread out over entire abdomen

Genotype
MGI:5473714

ht7

• Allelic Composition: Mcm4^chaos3/Mcm4^Sdla
• Genetic Background: involves: C57BL/6 * C57BL/6J

mortality/aging

prenatal lethality, complete penetrance ( J:194117 )

• no mice are present at P1

Genotype
MGI:4838110

cx8

• Allelic Composition: Mcm2^{Gt(AB0178)Wtsi}/Mcm2⁺; Mcm3^{Gt(RRR002)Byg}/Mcm3⁺; Mcm4^chaos3/Mcm4^chaos3
• Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J

mortality/aging

premature death ( J:165667 )

• lifespan is expanded compared to in Mcm2^{Gt(AB0178)Wtsi}/Mcm2⁺ Mcm4^chaos3/Mcm4^chaos3 mice but all mice die by 12 months of age

postnatal lethality, incomplete penetrance ( J:165667 )

• mortality observed in Mcm2^{Gt(AB0178)Wtsi}/Mcm2⁺ Mcm4^chaos3/Mcm4^chaos3 mice is largely rescued

neoplasm

increased tumor incidence ( J:165667 )

• onset of tumorigenesis (lymphoma, thymoma, bone tumors, and liver tumors) is delayed or eliminated compared with Mcm2^{Gt(AB0178)Wtsi}/Mcm2⁺ Mcm4^chaos3/Mcm4^chaos3 mice

hematopoietic system

hematopoietic system phenotype ( J:165667 )

N • the ratio of CD71+ reticulocytes to total red blood cells is completely corrected compared to in Mcm2^{Gt(AB0178)Wtsi}/Mcm2⁺ Mcm4^chaos3/Mcm4^chaos3 mice

abnormal erythrocyte morphology ( J:165667 )

• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with Mcm4^chaos3 homozygotes

cellular

decreased fibroblast proliferation ( J:165667 )

• mouse embryonic fibroblast proliferation (MEFs) is partially rescued compared to in Mcm2^{Gt(AB0178)Wtsi}/Mcm2⁺ Mcm4^chaos3/Mcm4^chaos3 MEFs

chromosomal instability ( J:165667 )

• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with Mcm4^chaos3 homozygotes

embryo

abnormal pluripotent precursor cell morphology ( J:165667 )

• mouse embryonic fibroblasts exhibit compromised ability to form induced pluripotent stem cells compared with Mcm4^chaos3/Mcm4^chaos3 cells but improved 2.5- to 10-fold compared with Mcm2^{Gt(AB0178)Wtsi}/Mcm2⁺ Mcm4^chaos3/Mcm4^chaos3 cells

growth/size/body

growth/size/body region phenotype ( J:165667 )

N • body weight is rescued compared with Mcm2^{Gt(AB0178)Wtsi}/Mcm2⁺ Mcm4^chaos3/Mcm4^chaos3 mice

Genotype
MGI:4838107

cx9

• Allelic Composition: Mcm2^{Gt(AB0178)Wtsi}/Mcm2⁺; Mcm4^chaos3/Mcm4^chaos3
• Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J

mortality/aging

premature death ( J:165667 )

• mice begin to die at 2 months and all mice die by 7 months of age

postnatal lethality ( J:165667 )

• fewer than expected mice are produced (no time point given)

neoplasm

increased tumor incidence ( J:165667 )

• mice exhibit lymphomas/leukemias

• three-quarters of mice develop tumors by 18 months

increased T cell derived lymphoma incidence ( J:165667 )

increased leukemia incidence ( J:165667 )

hematopoietic system

increased T cell derived lymphoma incidence ( J:165667 )

abnormal erythrocyte morphology ( J:165667 )

• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice and Mcm4^chaos3 homozygotes

reticulocytosis ( J:165667 )

• mice exhibit an increase in the number of CD71+ (proliferating cells, reticulocytes, erythroid precursors) cells compared with Mcm4^chaos3 homozygotes

cellular

decreased fibroblast proliferation ( J:165667 )

• in mouse embryonic fibroblasts after 5 days in culture

chromosomal instability ( J:165667 )

• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice and Mcm4^chaos3 homozygotes

embryo

abnormal pluripotent precursor cell morphology ( J:165667 )

• mouse embryonic fibroblasts exhibit compromised ability to form induced pluripotent stem cells compared with Mcm4^chaos3 homozygous cells

growth/size/body

decreased body weight ( J:165667 )

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:165667 )

immune system

increased T cell derived lymphoma incidence ( J:165667 )

Genotype
MGI:4838113

cx10

• Allelic Composition: Mcm3^{Gt(RRR002)Byg}/Mcm3⁺; Mcm4^chaos3/Mcm4^{Gt(RRE056)Byg}
• Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J

mortality/aging

premature death ( J:165667 )

• mice die sooner than Mcm4^chaos3 homozygotes

postnatal lethality, incomplete penetrance ( J:165667 )

• postnatal mortality observed in Mcm4^chaos3/Mcm4^{Gt(RRE056)Byg} mice is partially rescued

neoplasm

increased mammary gland tumor incidence ( J:165667 )

increased lymphoma incidence ( J:165667 )

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:165667 )

integument

increased mammary gland tumor incidence ( J:165667 )

Genotype
MGI:4838114

cx11

• Allelic Composition: Mcm3^{Gt(RRR002)Byg}/Mcm3⁺; Mcm4^chaos3/Mcm4^chaos3; Mcm6^{Gt(YHD248)Byg}/Mcm6⁺
• Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J

mortality/aging

postnatal lethality, incomplete penetrance ( J:165667 )

• mortality observed in Mcm4^chaos3/Mcm4^chaos3 Mcm6^{Gt(YHD248)Byg}/Mcm6⁺ mice is partially rescued

neoplasm

increased tumor incidence ( J:165667 )

• tumor latency is shorted than in Mcm4^chaos3 homozygotes

increased lymphoma incidence ( J:165667 )

Genotype
MGI:4838115

cx12

• Allelic Composition: Mcm3^{Gt(RRR002)Byg}/Mcm3⁺; Mcm4^chaos3/Mcm4^chaos3
• Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:165667 )

• onset of mammary gland tumorigenesis is delayed or eliminated compared with Mcm4^chaos3 homozygotes

mortality/aging

mortality/aging ( J:165667 )

N • lifespan is expanded compared to in Mcm4^chaos3 homozygotes

neoplasm

neoplasm ( J:165667 )

N • mice do not develop lymphomas or thymomas unlike Mcm4^chaos3 homozygotes

increased mammary gland tumor incidence ( J:165667 )

• onset of mammary gland tumorigenesis is delayed or eliminated compared with Mcm4^chaos3 homozygotes

integument

increased mammary gland tumor incidence ( J:165667 )

• onset of mammary gland tumorigenesis is delayed or eliminated compared with Mcm4^chaos3 homozygotes

embryo

abnormal pluripotent precursor cell morphology ( J:165667 )

• mouse embryonic fibroblasts exhibit increased ability to form induced pluripotent stem cells compared with Mcm4^chaos3/Mcm4^chaos3 cells

Genotype
MGI:4838116

cx13

• Allelic Composition: Mcm4^chaos3/Mcm4^chaos3; Mcm6^{Gt(YHD248)Byg}/Mcm6⁺
• Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J

mortality/aging

postnatal lethality, incomplete penetrance ( J:165667 )

• fewer than expected mice are produced

prenatal lethality, incomplete penetrance ( J:165667 )

• only 10% of expected mice survive to birth

growth/size/body

decreased body weight ( J:165667 )

Genotype
MGI:4838117

cx14

• Allelic Composition: Mcm4^chaos3/Mcm4^chaos3; Mcm7^{Gt(YTA285)Byg}/Mcm7⁺
• Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J

mortality/aging

postnatal lethality, incomplete penetrance ( J:165667 )

• only 8% of expected mice survive to weaning

prenatal lethality, incomplete penetrance ( J:165667 )

• 50% of expected mice are liveborn

hematopoietic system

abnormal erythrocyte morphology ( J:165667 )

• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with Mcm4^chaos3 homozygotes

reticulocytosis ( J:165667 )

• mice exhibit an increase in the number of CD71+ (proliferating cells, reticulocytes, erythroid precursors) cells compared with Mcm4^chaos3 homozygotes

cellular

chromosomal instability ( J:165667 )

• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with Mcm4^chaos3 homozygotes

growth/size/body

decreased body weight ( J:165667 )