Analysis Tools|
Allele Symbol Allele Name Allele ID |
Mcm4Gt(RRE056)Byg gene trap RRE056, BayGenomics MGI:3696796 |
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| Summary |
13 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• no postimplantation homozygous embryos are seen
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• proliferation of inner cell mass is not observed in blastocyst cultures
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• proliferation of inner cell mass is not observed in blastocyst cultures
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice
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• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• embryos are found until E14.5
• Background Sensitivity: on mixed backgrounds, mutants show extended survival
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• majority are growth retarded
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• majority are growth retarded
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• there are a lower number of cells in S phase and slightly increased G2/M populations compared to controls
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• mouse embryonic fibroblasts (MEFs) show a mild defect in proliferation
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• MEFs are highly susceptible to aphidicolin-induced chromosome breaks
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• double mutants are observed at E18.5; a small number survive past birth
(J:117494)
• Background Sensitivity: survival is extended compared to B6 congenic background
(J:117494)
• fewer than expected mice are alive at birth
(J:165667)
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• very few mice are present at weaning
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• at E18.5, animals are markedly smaller than control littermates
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• mice surviving to P2 show abnormal development of digestive system; milk spot appears diffuse and spread out over entire abdomen
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice
|
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• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice
|
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice
|
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• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice
|
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|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice
|
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• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice
|
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• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice
|
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• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice
|
|
• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice
|
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• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice die sooner than Mcm4chaos3 homozygotes
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• postnatal mortality observed in Mcm4chaos3/Mcm4Gt(RRE056)Byg mice is partially rescued
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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