Analysis Tools
digestive/alimentary system
|
• 18 out of 29 (62.1%) male mice develop submandibular gland tumors
• some males develop bilateral tumors
• female mice develop tumors infrequently
• tumor patterns vary from diffuse to variably defined lobules or discrete nests with a fibrous stroma
• many tumor cell nuclei are hyperchromatic
• some lesions are undifferentiated, often with a foci of necrosis
• many tumors are unencapsulated, others have broad expansive margins
• dysplasia occurs only in cells of intercalated ducts
|
|
• dysplasia occurs only in cells of intercalated ducts
• gland has multiple aggregates of abnormal ducts and gland-like structures
• abnormal ducts lined by moderately crowded cells with hyperchromatic nuclei are observed in 30 day old mice
• aggregates of hyperplastic/dysplastic ducts are present at 4-6 months of age
• duct lumen is displaced or reduced in size
• no abnormalities are detected in acinar, striated duct or granular convoluted tubule cells
• parotid and sublingual glands are not affected
|
endocrine/exocrine glands
|
• 18 out of 29 (62.1%) male mice develop submandibular gland tumors
• some males develop bilateral tumors
• female mice develop tumors infrequently
• tumor patterns vary from diffuse to variably defined lobules or discrete nests with a fibrous stroma
• many tumor cell nuclei are hyperchromatic
• some lesions are undifferentiated, often with a foci of necrosis
• many tumors are unencapsulated, others have broad expansive margins
• dysplasia occurs only in cells of intercalated ducts
|
|
• dysplasia occurs only in cells of intercalated ducts
• gland has multiple aggregates of abnormal ducts and gland-like structures
• abnormal ducts lined by moderately crowded cells with hyperchromatic nuclei are observed in 30 day old mice
• aggregates of hyperplastic/dysplastic ducts are present at 4-6 months of age
• duct lumen is displaced or reduced in size
• no abnormalities are detected in acinar, striated duct or granular convoluted tubule cells
• parotid and sublingual glands are not affected
|
neoplasm
|
• 18 out of 29 (62.1%) male mice develop submandibular gland tumors
• some males develop bilateral tumors
• female mice develop tumors infrequently
• tumor patterns vary from diffuse to variably defined lobules or discrete nests with a fibrous stroma
• many tumor cell nuclei are hyperchromatic
• some lesions are undifferentiated, often with a foci of necrosis
• many tumors are unencapsulated, others have broad expansive margins
• dysplasia occurs only in cells of intercalated ducts
|
growth/size/body
|
• 18 out of 29 (62.1%) male mice develop submandibular gland tumors
• some males develop bilateral tumors
• female mice develop tumors infrequently
• tumor patterns vary from diffuse to variably defined lobules or discrete nests with a fibrous stroma
• many tumor cell nuclei are hyperchromatic
• some lesions are undifferentiated, often with a foci of necrosis
• many tumors are unencapsulated, others have broad expansive margins
• dysplasia occurs only in cells of intercalated ducts
|
craniofacial
|
• 18 out of 29 (62.1%) male mice develop submandibular gland tumors
• some males develop bilateral tumors
• female mice develop tumors infrequently
• tumor patterns vary from diffuse to variably defined lobules or discrete nests with a fibrous stroma
• many tumor cell nuclei are hyperchromatic
• some lesions are undifferentiated, often with a foci of necrosis
• many tumors are unencapsulated, others have broad expansive margins
• dysplasia occurs only in cells of intercalated ducts
|
