All Phenotypes Atp1a3<tm1Ling> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Atp1a3^tm1Ling
targeted mutation 1, Jerry B Lingrel
MGI:3696954

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Atp1a3^tm1Ling/Atp1a3^tm1Ling	involves: 129 * Black Swiss	MGI:3697484
ht2	Atp1a3^tm1Ling/Atp1a3⁺	involves: 129 * Black Swiss	MGI:3697485
ht3	Atp1a3^Myk/Atp1a3^tm1Ling	involves: 129S1/SvImJ * C57BL/6J * C57BL/6NCr	MGI:4356172

Allelic Composition	Atp1a3^tm1Ling/Atp1a3^tm1Ling
Genetic Background	involves: 129 * Black Swiss

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp1a3^tm1Ling mutation (0 available); any Atp1a3 mutation (70 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:117414 )

• die shortly after birth

Allelic Composition	Atp1a3^tm1Ling/Atp1a3⁺
Genetic Background	involves: 129 * Black Swiss

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp1a3^tm1Ling mutation (0 available); any Atp1a3 mutation (70 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

enhanced behavioral response to addictive substance ( J:117414 )

• increase in peak activity elicited by methamphetamine

abnormal spatial learning ( J:117414 )

• increased latency to find the platform in a Morris water maze

hyperactivity ( J:117414 )

• significant increase in activity in the first 4 time intervals in an open field

• increase in peak activity elicited by methamphetamine

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:117414 )

N	• circulating levels of corticosterone, norepinephrine, dopamine, serotonin, and their metabolites are all similar to wild-type mice

Allelic Composition	Atp1a3^Myk/Atp1a3^tm1Ling
Genetic Background	involves: 129S1/SvImJ * C57BL/6J * C57BL/6NCr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp1a3^Myk mutation (3 available); any Atp1a3 mutation (70 available)
Atp1a3^tm1Ling mutation (0 available); any Atp1a3 mutation (70 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:151948 )

• no mice were present at 4 weeks (time of death not given)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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