All Phenotypes Cltrn<tm1.1Pngr> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Cltrn^tm1.1Pngr
targeted mutation 1.1, Joseph M Penninger
MGI:3696995

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cltrn^tm1.1Pngr/Cltrn^tm1.1Pngr	involves: 129P2/OlaHsd * C57BL/6J	MGI:3697465

Allelic Composition	Cltrn^tm1.1Pngr/Cltrn^tm1.1Pngr
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cltrn^tm1.1Pngr mutation (0 available); any Cltrn mutation (9 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

increased urine osmolality ( J:117490 )

• mutants have higher concentration of osmotically active solutes in urine

abnormal renal transport ( J:117490 )

• uptake rate of amino acids in brush border membrane vesicles (BBMV) is decreased relative to controls

polyuria ( J:117490 )

• urine output by Tmem27-deficient males is higher (3.31 ml/24 hours) than in wild-type males (1.65 ml/24 hours)

homeostasis/metabolism

abnormal homeostasis ( J:117490 )

increased urine osmolality ( J:117490 )

• mutants have higher concentration of osmotically active solutes in urine

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