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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Psrs1PL/J
PL/J
MGI:3697146
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Itgb2tm1Bay/Itgb2tm1Bay
Psrs1PL/J/Psrs1PL/J 		B6.Cg-(D10Mit126-D10Mit38) Itgb2tm1Bay MGI:3790701
cx2
 		Itgb2tm1Bay/Itgb2tm1Bay
Psrs1PL/J/Psrs1PL/J 		B6.Cg-(D10Mit75-D10Mit271) Itgb2tm1Bay MGI:3790702
cx3
 		Itgb2tm1Bay/?
Psrs1PL/J/? 		involves: 129S7/SvEvBrd * C57BL/6J * PL/J MGI:3697182


Genotype
MGI:3790701
cx1
Allelic
Composition		 Itgb2tm1Bay/Itgb2tm1Bay
Psrs1PL/J/Psrs1PL/J
Genetic
Background		 B6.Cg-(D10Mit126-D10Mit38) Itgb2tm1Bay
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgb2tm1Bay mutation (1 available); any Itgb2 mutation (50 available)
Psrs1PL/J mutation (0 available); any Psrs1 mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
rheumatoid arthritis ( J:134251 )
• increased susceptibility to rheumatoid arthritis
• 75% incidence of rheumatoid arthritis at 16 weeks of age
• presence of swelling and erythema at ankle joints and tarsometarasal/metatarsophalangeal paw joints
• presence of inflammatory cell infiltrates in bones
• cartilage damage

skeleton
rheumatoid arthritis ( J:134251 )
• increased susceptibility to rheumatoid arthritis
• 75% incidence of rheumatoid arthritis at 16 weeks of age
• presence of swelling and erythema at ankle joints and tarsometarasal/metatarsophalangeal paw joints
• presence of inflammatory cell infiltrates in bones
• cartilage damage

integument
psoriasis ( J:134251 )
• increased psoriasis susceptibility
• 87.5% incidence of psoriasis at 16 weeks of age
• severe progressive erythema and scale and crust formation on the back skin
• presence of epidermal hyperplasia, hyperorthokeratosis and subcorneal microabscesses
• presence of inflammatory cell infiltration (CD4+ cells and macrophages) in the dermis




Genotype
MGI:3790702
cx2
Allelic
Composition		 Itgb2tm1Bay/Itgb2tm1Bay
Psrs1PL/J/Psrs1PL/J
Genetic
Background		 B6.Cg-(D10Mit75-D10Mit271) Itgb2tm1Bay
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgb2tm1Bay mutation (1 available); any Itgb2 mutation (50 available)
Psrs1PL/J mutation (0 available); any Psrs1 mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
rheumatoid arthritis ( J:134251 )
• increased susceptibility to rheumatoid arthritis
• 78.6% incidence of rheumatoid arthritis at 16 weeks of age
• presence of swelling and erythema at ankle joints and tarsometarasal/metatarsophalangeal paw joints
• presence of inflammatory cell infiltrates in bones
• cartilage damage

skeleton
rheumatoid arthritis ( J:134251 )
• increased susceptibility to rheumatoid arthritis
• 78.6% incidence of rheumatoid arthritis at 16 weeks of age
• presence of swelling and erythema at ankle joints and tarsometarasal/metatarsophalangeal paw joints
• presence of inflammatory cell infiltrates in bones
• cartilage damage

integument
psoriasis ( J:134251 )
• increased psoriasis susceptibility
• 100% incidence of psoriasis at 16 weeks of age
• severe progressive erythema and scale and crust formation on the back skin
• presence of epidermal hyperplasia, hyperorthokeratosis and subcorneal microabscesses
• presence of inflammatory cell infiltration (CD4+ cells and macrophages) in the dermis




Genotype
MGI:3697182
cx3
Allelic
Composition		 Itgb2tm1Bay/?
Psrs1PL/J/?
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6J * PL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgb2tm1Bay mutation (1 available); any Itgb2 mutation (50 available)
Psrs1PL/J mutation (0 available); any Psrs1 mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
integument
psoriasis ( J:117544 )
• earlier psoriasis onset
• increased psoriasis susceptibility




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory