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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Sox13tm1Jskg
targeted mutation 1, Joonsoo Kang
MGI:3697320
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Sox13tm1Jskg/Sox13tm1Jskg involves: C57BL/6 MGI:3697908
ht2
 		Sox13tm1Jskg/Sox13+ involves: C57BL/6 MGI:3697909


Genotype
MGI:3697908
hm1
Allelic
Composition		 Sox13tm1Jskg/Sox13tm1Jskg
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox13tm1Jskg mutation (0 available); any Sox13 mutation (58 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
abnormal postnatal growth/weight/body size ( J:117301 )
• homozygotes display developmental abnormalities
postnatal growth retardation ( J:117301 )
• at 3 weeks of age, mutants are many-fold smaller than littermate controls

hematopoietic system
increased T cell proliferation ( J:117301 )
• gamma-delta and triple negative thymocytes show enhanced proliferation in mutants
decreased gamma-delta T cell number ( J:117301 )
• at E18.5, a decrease in number and proportion of gamma-deltal TCR+ (T cell receptor) cells is observed compared to littermate controls and heterozygotes

immune system
increased T cell proliferation ( J:117301 )
• gamma-delta and triple negative thymocytes show enhanced proliferation in mutants
decreased gamma-delta T cell number ( J:117301 )
• at E18.5, a decrease in number and proportion of gamma-deltal TCR+ (T cell receptor) cells is observed compared to littermate controls and heterozygotes

cellular
increased T cell proliferation ( J:117301 )
• gamma-delta and triple negative thymocytes show enhanced proliferation in mutants




Genotype
MGI:3697909
ht2
Allelic
Composition		 Sox13tm1Jskg/Sox13+
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox13tm1Jskg mutation (0 available); any Sox13 mutation (58 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased gamma-delta T cell number ( J:117301 )
• at E18.5, a decrease in number and proportion of gamma-deltal TCR+ (T cell receptor) cells is observed compared to littermate controls

immune system
decreased gamma-delta T cell number ( J:117301 )
• at E18.5, a decrease in number and proportion of gamma-deltal TCR+ (T cell receptor) cells is observed compared to littermate controls




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory