Analysis Tools|
Allele Symbol Allele Name Allele ID |
Mad1l1tm1.1Ktj targeted mutation 1.1, Kuan-Teh Jeang MGI:3697324 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• chromosomal instability is much higher than in wild-type MEFs
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• 6% of MEFs are aneuploid for chromosome 2 compared to 1.4% of wild-type MEFs
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• mutant MEFs injected into athymic nude mice produced tumors in 3/8 mice compared to no tumors from wild-type MEFs; tumors grow slowly and are not palpable until weeks 6 to 10
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• stringency of spindle assembly checkpoint (SAC) mediated arrest in response to nocodazole is weaker in mutant MEFs
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• when assayed at 18 moths of age, heterozygotes show increased tumor incidence compared to wild-type
• mutant MEFs induce tumors in 100% of athymic nude mice in 4 weeks
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• uterine carcinoma is observed in some mice at 18 months of age
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• observed in some mice at 18 months of age with higher incidence than in wild-type
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• observed in some mice at 18 months of age with higher incidence than in wild-type
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• uterine sarcoma is observed in some mice at 18 months of age
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• observed in some mice at 18 months of age with higher incidence than in wild-type
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• observed in some mice at 18 months of age with higher incidence than in wild-type
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• observed in some mice at 18 months of age with higher incidence than in wild-type
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• observed in some mice at 18 months of age with higher incidence than in wild-type
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• observed in some mice at 18 months of age with higher incidence than in wild-type
|
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• observed in some mice at 18 months of age with higher incidence than in wild-type
|
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• observed in some mice at 18 months of age with higher incidence than in wild-type
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mutant MEFs induce tumors in 100% of athymic nude mice in 4 weeks
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• chromosomal instability is much higher than in wild-type MEFs
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• 14.5% of MEFs are aneuploid for chromosome 2 compared to 1.4% of wild-type MEFs
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• mutant MEFs injected into athymic nude mice produced tumors in 8/8 mice within 4 weeks compared to no tumors from wild-type MEFs
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• stringency of spindle assembly checkpoint (SAC) mediated arrest in response to nocodazole is weaker in mutant MEFs
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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