Allele Symbol Allele Name Allele ID |
Mad1l1tm1.1Ktj targeted mutation 1.1, Kuan-Teh Jeang MGI:3697324 |
||||||||||||||||
Summary |
3 genotypes
|
|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• chromosomal instability is much higher than in wild-type MEFs
|
• 6% of MEFs are aneuploid for chromosome 2 compared to 1.4% of wild-type MEFs
|
• mutant MEFs injected into athymic nude mice produced tumors in 3/8 mice compared to no tumors from wild-type MEFs; tumors grow slowly and are not palpable until weeks 6 to 10
|
• stringency of spindle assembly checkpoint (SAC) mediated arrest in response to nocodazole is weaker in mutant MEFs
|
• when assayed at 18 moths of age, heterozygotes show increased tumor incidence compared to wild-type
• mutant MEFs induce tumors in 100% of athymic nude mice in 4 weeks
|
• uterine carcinoma is observed in some mice at 18 months of age
|
• observed in some mice at 18 months of age with higher incidence than in wild-type
|
• observed in some mice at 18 months of age with higher incidence than in wild-type
|
• uterine sarcoma is observed in some mice at 18 months of age
|
• observed in some mice at 18 months of age with higher incidence than in wild-type
|
• observed in some mice at 18 months of age with higher incidence than in wild-type
|
• observed in some mice at 18 months of age with higher incidence than in wild-type
|
• observed in some mice at 18 months of age with higher incidence than in wild-type
|
• observed in some mice at 18 months of age with higher incidence than in wild-type
|
• observed in some mice at 18 months of age with higher incidence than in wild-type
|
• observed in some mice at 18 months of age with higher incidence than in wild-type
|
|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• mutant MEFs induce tumors in 100% of athymic nude mice in 4 weeks
|
• chromosomal instability is much higher than in wild-type MEFs
|
• 14.5% of MEFs are aneuploid for chromosome 2 compared to 1.4% of wild-type MEFs
|
• mutant MEFs injected into athymic nude mice produced tumors in 8/8 mice within 4 weeks compared to no tumors from wild-type MEFs
|
• stringency of spindle assembly checkpoint (SAC) mediated arrest in response to nocodazole is weaker in mutant MEFs
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 08/02/2024 MGI 6.24 |
![]() |
|