Phenotypes associated with this allele

• Allele Symbol: Tg(CAG-Tle1,-ALPP)1Lbe
• Allele Name: transgene insertion 1, Corrinne Lobe
• Allele ID: MGI:3697397
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Tg(CAG-Aes,-ALPP)1Lbe/0 Tg(CAG-Tle1,-ALPP)1Lbe/0	involves: 129S1/Sv * 129X1/SvJ * CD-1	MGI:3697422
tg2	Tg(CAG-Tle1,-ALPP)1Lbe/0	involves: 129S1/Sv * 129X1/SvJ * CD-1	MGI:3697420

Genotype
MGI:3697422

cx1

• Allelic Composition: Tg(CAG-Aes,-ALPP)1Lbe/0; Tg(CAG-Tle1,-ALPP)1Lbe/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

abnormal tumor susceptibility ( J:106684 )

• only 50% (6/12) double transgenic mice have visible tumors on the pleural surface compared to 96% (27/28) of Tg(ACTB-Tle1,-ALPP)1Lbe single transgenics at 6 months of age

• average number of visible tumors is 2.4 compared to 8.3 in single transgenic mice; tumors are substantially smaller in addition to being decreased in number

decreased lung tumor incidence ( J:106684 )

respiratory system

decreased lung tumor incidence ( J:106684 )

Genotype
MGI:3697420

tg2

• Allelic Composition: Tg(CAG-Tle1,-ALPP)1Lbe/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

neoplasm

increased lung adenocarcinoma incidence ( J:106684 )

• adults develop lung tumors with 100% penetrance

• neoplasms appear at 1 month resembling noninvasive bronchioalveolar carcinoma; at 3-5 months, visible tumor nodules are noted on the pleural surface with extensive proliferation, but preserving their bronchioalveolar growth pattern

• between 5 and 6 months, number of visible lesions on pleural surface increases from 3.2 to 8.3/mouse

• by 8 months, some lesions appear as whitish solid tumor masses characteristic of invasive cancer; such tumors replace large areas of lung parenchyma and show areas of necrosis

• tumor cells are tall columnar epithelial cells showing a mix of papillary, acinar, as well as bronchioalveolar growth patterns; there is prominent extracellular mucin secretion that causes destruction of alveolar septae

• alveolar and terminal bronchioles are lined with dysplastic epithelial cells with pleomorphic, enlarged ,irregular nuclei

respiratory system

increased lung adenocarcinoma incidence ( J:106684 )

• adults develop lung tumors with 100% penetrance

• neoplasms appear at 1 month resembling noninvasive bronchioalveolar carcinoma; at 3-5 months, visible tumor nodules are noted on the pleural surface with extensive proliferation, but preserving their bronchioalveolar growth pattern

• between 5 and 6 months, number of visible lesions on pleural surface increases from 3.2 to 8.3/mouse

• by 8 months, some lesions appear as whitish solid tumor masses characteristic of invasive cancer; such tumors replace large areas of lung parenchyma and show areas of necrosis

• tumor cells are tall columnar epithelial cells showing a mix of papillary, acinar, as well as bronchioalveolar growth patterns; there is prominent extracellular mucin secretion that causes destruction of alveolar septae

• alveolar and terminal bronchioles are lined with dysplastic epithelial cells with pleomorphic, enlarged ,irregular nuclei