Phenotypes associated with this allele

• Allele Symbol: Tg(CAG-Aes,-ALPP)1Lbe
• Allele Name: transgene insertion 1, Corrinne Lobe
• Allele ID: MGI:3697400
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Tg(CAG-Aes,-ALPP)1Lbe/0 Tg(CAG-Tle1,-ALPP)1Lbe/0	involves: 129S1/Sv * 129X1/SvJ * CD-1	MGI:3697422
tg2	Tg(CAG-Aes,-ALPP)1Lbe/0	involves: 129S1/Sv * 129X1/SvJ * CD-1	MGI:3697421

Genotype
MGI:3697422

cx1

• Allelic Composition: Tg(CAG-Aes,-ALPP)1Lbe/0; Tg(CAG-Tle1,-ALPP)1Lbe/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

abnormal tumor susceptibility ( J:106684 )

• only 50% (6/12) double transgenic mice have visible tumors on the pleural surface compared to 96% (27/28) of Tg(ACTB-Tle1,-ALPP)1Lbe single transgenics at 6 months of age

• average number of visible tumors is 2.4 compared to 8.3 in single transgenic mice; tumors are substantially smaller in addition to being decreased in number

decreased lung tumor incidence ( J:106684 )

respiratory system

decreased lung tumor incidence ( J:106684 )

Genotype
MGI:3697421

tg2

• Allelic Composition: Tg(CAG-Aes,-ALPP)1Lbe/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

normal phenotype

no abnormal phenotype detected ( J:106684 )

• mice are viable and fertile, with no obvious phenotypic abnormalities