Phenotypes associated with this allele

• Allele Symbol: Cbln3^tm1Jim
• Allele Name: targeted mutation 1, James I Morgan
• Allele ID: MGI:3697442
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cbln3^tm1Jim/Cbln3^tm1Jim	involves: 129S7/SvEvBrd	MGI:3697901
cx2	Cbln1^tm1Jim/Cbln1^+ Cbln3^tm1Jim/Cbln3^tm1Jim	involves: 129S7/SvEvBrd	MGI:3697902
cx3	Cbln1^tm1Jim/Cbln1^tm1Jim Cbln3^tm1Jim/Cbln3^tm1Jim	involves: 129S7/SvEvBrd	MGI:3697903

Genotype
MGI:3697901

hm1

• Allelic Composition: Cbln3^tm1Jim/Cbln3^tm1Jim
• Genetic Background: involves: 129S7/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:117650 )

• mice are viable and fertile with no gross abnormalities, normal cerbellar foliation and lamination, normal Purkinje cell morphology, and no obvious behavioral defects

Genotype
MGI:3697902

cx2

• Allelic Composition: Cbln1^tm1Jim/Cbln1⁺; Cbln3^tm1Jim/Cbln3^tm1Jim
• Genetic Background: involves: 129S7/SvEvBrd

normal phenotype

no abnormal phenotype detected ( J:117650 )

• mice are viable and fertile with no gross abnormalities and normal neuroanatomical and behavioral phenotypes

Genotype
MGI:3697903

cx3

• Allelic Composition: Cbln1^tm1Jim/Cbln1^tm1Jim; Cbln3^tm1Jim/Cbln3^tm1Jim
• Genetic Background: involves: 129S7/SvEvBrd

behavior/neurological

abnormal motor capabilities/coordination/movement ( J:117650 )

• phenotype is stated to be identical to Cbln1 single homozygotes; however, no data is shown

ataxia ( J:117650 )

impaired coordination ( J:117650 )

abnormal gait ( J:117650 )

nervous system

abnormal nervous system morphology ( J:117650 )

• phenotype is stated to be identical to Cbln1 single homozygotes; however, no data is shown

abnormal cerebellar granule layer morphology ( J:117650 )

abnormal Purkinje cell innervation ( J:117650 )