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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Hrctm1Blk
targeted mutation 1, Brian L Black
MGI:3697445
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Hrctm1Blk/Hrctm1Blk B6.129S6-Hrctm1Blk MGI:3697617
ht2
 		Hrctm1Blk/Hrc+ B6.129S6-Hrctm1Blk MGI:3697618


Genotype
MGI:3697617
hm1
Allelic
Composition		 Hrctm1Blk/Hrctm1Blk
Genetic
Background		 B6.129S6-Hrctm1Blk
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hrctm1Blk mutation (0 available); any Hrc mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
decreased body weight ( J:117648 )
• exhibit impaired weight gain beginning at 11 months of age
weight loss ( J:117648 )
• exhibit weight loss beginning at 11 months of age

cardiovascular system
cardiovascular system phenotype ( J:117648 )
N
• hearts exhibit normal calcium handling
increased response of heart to induced stress ( J:117648 )
• display increased susceptibility to isoproterenol-induced cardiac hypertrophy

adipose tissue
abnormal fat pad morphology ( J:117648 )
• impaired weight gain is marked by reduced fat pad mass

muscle
decreased skeletal muscle mass ( J:117648 )
• impaired weight gain is marked by reduced skeletal muscle mass

behavior/neurological
behavior/neurological phenotype ( J:117648 )
N
• exhibit no difference in voluntary exercise performance compared to wild-type

homeostasis/metabolism
increased response of heart to induced stress ( J:117648 )
• display increased susceptibility to isoproterenol-induced cardiac hypertrophy




Genotype
MGI:3697618
ht2
Allelic
Composition		 Hrctm1Blk/Hrc+
Genetic
Background		 B6.129S6-Hrctm1Blk
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hrctm1Blk mutation (0 available); any Hrc mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
increased response of heart to induced stress ( J:117648 )
• display increased susceptibility to isoproterenol-induced cardiac hypertrophy compared than wild-type, although to a lesser extent than in homozygotes

homeostasis/metabolism
increased response of heart to induced stress ( J:117648 )
• display increased susceptibility to isoproterenol-induced cardiac hypertrophy compared than wild-type, although to a lesser extent than in homozygotes




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory