About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Camkk1tm1Tch
targeted mutation 1, Talal A Chatila
MGI:3697455
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Camkk1tm1Tch/Camkk1tm1Tch involves: 129X1/SvJ * C57BL/6 MGI:3697816
cx2
 		Camkk1tm1Tch/Camkk1tm1Tch
Camkk2tm1Tch/Camkk2tm1Tch 		involves: 129X1/SvJ MGI:4941485


Genotype
MGI:3697816
hm1
Allelic
Composition		 Camkk1tm1Tch/Camkk1tm1Tch
Genetic
Background		 involves: 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Camkk1tm1Tch mutation (1 available); any Camkk1 mutation (20 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal contextual conditioning behavior ( J:117630 )
• exhibit significantly less freezing at 24h and 10, 30, and 63 days in a long-term fear memory context test
• however, freezing in long term fear cued (tone) test is similar to wild-type, no difference in anxiety related behavior is found, and no motor defects are detected

nervous system
nervous system phenotype ( J:117630 )
N
• basal synaptic transmission and long term potentiation in CA1 neurons are similar to wild-type

reproductive system




Genotype
MGI:4941485
cx2
Allelic
Composition		 Camkk1tm1Tch/Camkk1tm1Tch
Camkk2tm1Tch/Camkk2tm1Tch
Genetic
Background		 involves: 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Camkk1tm1Tch mutation (1 available); any Camkk1 mutation (20 available)
Camkk2tm1Tch mutation (1 available); any Camkk2 mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal axon morphology ( J:169657 )
• axons and dendrites of cortical neurons are shortened compared to in wild-type cells
abnormal dendrite morphology ( J:169657 )
• axons and dendrites of cortical neurons are shortened compared to in wild-type cells




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory