Phenotypes associated with this allele

• Allele Symbol: Abca2^tm1Kdt
• Allele Name: targeted mutation 1, Kenneth D Tew
• Allele ID: MGI:3697467
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Abca2^tm1Kdt/Abca2^tm1Kdt	involves: 129	MGI:3697680

Genotype
MGI:3697680

hm1

• Allelic Composition: Abca2^tm1Kdt/Abca2^tm1Kdt
• Genetic Background: involves: 129

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body weight ( J:117673 )

• lower body weight in males at 5-6 weeks of age, and in females from 4-14 weeks compared to controls

behavior/neurological

increased fear-related response ( J:117673 )

• mice are more frightened by handlers, and are more difficult to catch by the tail compared to wild-type littermates

increased startle reflex ( J:117673 )

• mice are more easily startled by sound

tremors ( J:117673 )

• tremors in fore and hindlimbs is observed on balance beam or upon suspension by tail; abrupt undulating movements along spine are seen when mice are suspended

• during ambulation, shaking motion of ears, tail and body are observed in contrast to control littermates

abnormal motor coordination/balance ( J:117673 )

• impaired ability to counterbalance body weight on 4 paws when placed perpendicular to beam

• mutants move more rapidly on beam, with tendency to fall, compared to wild-type

enhanced coordination ( J:117673 )

• mutants perform better on rotarod apparatus at 4, 8, and 15 weeks of age

increased vertical activity ( J:117673 )

• increased rearing and increased climbing behavior compared to controls is observed

increased locomotor activity ( J:117673 )

• increased movement in cages is seen in males at 30- and 55-minute time points and in females from 10 to 60 minutes, along with increased climbing behavior

nervous system

abnormal myelin sheath morphology ( J:117673 )

• in cerebrum, more axons in mutants (24.1%) are in smallest range of myelin thickness than in wild-type (12.8%); more wild-type cerebral axons are in higher size ranges (8.5% with .16-.2 um thickness; 7.5% with >.21 um myelin thickness) compared to mutants (5% and 0%); mutant axons show hypomyelination

• in spinal cord, less axons (23.2%) in mutants have lower sheath measurements than in wild-type (34.4%); mutant axons predominate in higher (13.6% at .65-.94 um; 10.6% at >.94%) compared to wild-type (4.5% and 1.4%, respectively); mutant axons are hypermyelinated

• average myelin sheath thickness in spinal cord of female mutants (0.2 um) is increased vs wild-type (.12 um)

• in cerebrum and spinal cord of mutants, reduced periodicity and compaction of myelin is displayed