All Phenotypes Acvr2b<tm1.1Spo> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Acvr2b^tm1.1Spo
targeted mutation 1.1, S Paul Oh
MGI:3697600

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Acvr2b^tm1.1Spo/Acvr2b^tm1.1Spo	involves: 129S4/SvJae * FVB/N	MGI:3697595
cx2	Acvr2a^tm1Hsch/Acvr2a⁺ Acvr2b^tm1.1Spo/Acvr2b^tm1.1Spo	involves: 129S1/Sv * 129S4/SvJae * FVB/N	MGI:3697597
cx3	Acvr2a^tm1Hsch/Acvr2a^tm1Hsch Acvr2b^tm1.1Spo/Acvr2b^tm1.1Spo	involves: 129S1/Sv * 129S4/SvJae * FVB/N	MGI:3697598

Allelic Composition	Acvr2b^tm1.1Spo/Acvr2b^tm1.1Spo
Genetic Background	involves: 129S4/SvJae * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Acvr2b^tm1.1Spo mutation (0 available); any Acvr2b mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

vertebral transformation ( J:114533 )

• only 3 of 21 exhibit vertebral transformation, a significant decrease in the defects seen in Acvr2b^tm1Spo homozygotes

Allelic Composition	Acvr2a^tm1Hsch/Acvr2a⁺ Acvr2b^tm1.1Spo/Acvr2b^tm1.1Spo
Genetic Background	involves: 129S1/Sv * 129S4/SvJae * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Acvr2a^tm1Hsch mutation (0 available); any Acvr2a mutation (40 available)
Acvr2b^tm1.1Spo mutation (0 available); any Acvr2b mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

lumbar vertebral transformation ( J:114533 )

• 6 of 16 exhibit transformation of the 21st vertebra into the 14th thoracic vertebra

embryo

abnormal left-right axis patterning ( J:114533 )

• 12 of 13 show effects associated with left-right asymmetry such as right pulmonary isomerism and transposition of great arteries

cardiovascular system

transposition of great arteries ( J:114533 )

respiratory system

right pulmonary isomerism ( J:114533 )

growth/size/body

right pulmonary isomerism ( J:114533 )

Allelic Composition	Acvr2a^tm1Hsch/Acvr2a^tm1Hsch Acvr2b^tm1.1Spo/Acvr2b^tm1.1Spo
Genetic Background	involves: 129S1/Sv * 129S4/SvJae * FVB/N

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality between somite formation and embryo turning ( J:114533 )

embryo

embryonic growth arrest ( J:114533 )

• development is arrested at the gastrulation stage (E8.5)

abnormal embryonic tissue morphology ( J:114533 )

• the embryonic tissues grow outside of the yolk sac

embryonic-extraembryonic boundary constriction ( J:114533 )

• exhibit constrictions at the junction between the extraembryonic and embryonic regions at E7.5

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24