Phenotypes associated with this allele

• Allele Symbol: Sulf2^{Gt(XST155)Byg}
• Allele Name: gene trap XST155, BayGenomics
• Allele ID: MGI:3697687
• Summary: 6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sulf2^Gt(XST155)Byg/Sulf2^Gt(XST155)Byg	B6.129P2-Sulf2^Gt(XST155)Byg	MGI:3699296
hm2	Sulf2^Gt(XST155)Byg/Sulf2^Gt(XST155)Byg	FVB.129P2(B6)-Sulf2^Gt(XST155)Byg	MGI:3699285
hm3	Sulf2^Gt(XST155)Byg/Sulf2^Gt(XST155)Byg	involves: 129P2/OlaHsd * C57BL/6	MGI:3699290
hm4	Sulf2^Gt(XST155)Byg/Sulf2^Gt(XST155)Byg	involves: 129P2/OlaHsd * C57BL/6 * FVB/N	MGI:3699289
ht5	Sulf2^Gt(XST155)Byg/Sulf2^+	involves: 129P2/OlaHsd * C57BL/6	MGI:3699291
cx6	Ext2^tm1Werb/Ext2^+ Sulf2^Gt(XST155)Byg/Sulf2^Gt(XST155)Byg	involves: 129P2/OlaHsd * C57BL/6	MGI:3699302

Genotype
MGI:3699296

hm1

• Allelic Composition: Sulf2^{Gt(XST155)Byg}/Sulf2^{Gt(XST155)Byg}
• Genetic Background: B6.129P2-Sulf2^{Gt(XST155)Byg}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:117689 )

N • Background Sensitivity: on congenic B6 background, normal Mendelian numbers of homozygous pups are observed

Genotype
MGI:3699285

hm2

• Allelic Composition: Sulf2^{Gt(XST155)Byg}/Sulf2^{Gt(XST155)Byg}
• Genetic Background: FVB.129P2(B6)-Sulf2^{Gt(XST155)Byg}

mortality/aging

mortality/aging ( J:117689 )

N • Background Sensitivity: on this background, lethality is not observed compared to the mixed B6 background

reproductive system

reduced female fertility ( J:117689 )

♀ • homozygotes do not exhibit significantly reduced fertility when crossed to wild-type males, but when crossed to homozygous males, litter size is reduced (from ~8 pups/litter to 3 pups/litter)

reduced male fertility ( J:117689 )

♂ • homozygotes do not exhibit significantly reduced fertility when crossed to wild-type females, but when crossed to homozygous females, litter size is reduced (from ~8 pups/litter to 3 pups/litter)

Genotype
MGI:3699290

hm3

• Allelic Composition: Sulf2^{Gt(XST155)Byg}/Sulf2^{Gt(XST155)Byg}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

mortality/aging

postnatal lethality, incomplete penetrance ( J:117689 )

• at 3 weeks, number of homozygous mice is 48% of wild-type and only 29% of expected Mendelian number

embryonic lethality during organogenesis, incomplete penetrance ( J:117689 )

• significantly fewer homozygous embryos are found at E13.5 and 14.5; dead embryos appear to have terminated sometime from E10.5 to 12.5

growth/size/body

decreased embryo size ( J:117689 )

• many homozygous embryos and their placentas are smaller than wild-type embryos

• Background Sensitivity: at N3F3 generation (intercross of hets after third backcross to B6), expected number of homozygotes is obtained

decreased body size ( J:117689 )

• some homozygous pups (6/8 total runted pups) are severely runted with weights ~50% that of littermates at birth; runted mice are euthanized at various time points for health reasons

decreased body weight ( J:117689 )

• many homozygotes appear smaller than littermates after weaning, and weigh significantly less than wild-type littermates at 41.5 days

• at 1 year, homozygous mice have weights ~25% lower than littermates

embryo

decreased embryo size ( J:117689 )

• many homozygous embryos and their placentas are smaller than wild-type embryos

• Background Sensitivity: at N3F3 generation (intercross of hets after third backcross to B6), expected number of homozygotes is obtained

respiratory system

abnormal lung development ( J:117689 )

• 3 runted mice exhibited enlarged airspaces

respiratory distress ( J:117689 )

• a portion of runted homozygotes gasp after birth, suggesting respiratory distress and lung problems

Genotype
MGI:3699289

hm4

• Allelic Composition: Sulf2^{Gt(XST155)Byg}/Sulf2^{Gt(XST155)Byg}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

mortality/aging

mortality/aging ( J:117689 )

N • Background Sensitivity: on this background, lethality is not observed compared to the mixed B6 background

Genotype
MGI:3699291

ht5

• Allelic Composition: Sulf2^{Gt(XST155)Byg}/Sulf2⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

growth/size/body

decreased body size ( J:117689 )

• some heterozygous pups (2/8 total runted pups) are severely runted with weights ~50% that of littermates at birth

Genotype
MGI:3699302

cx6

• Allelic Composition: Ext2^tm1Werb/Ext2⁺; Sulf2^{Gt(XST155)Byg}/Sulf2^{Gt(XST155)Byg}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

mortality/aging

prenatal lethality, incomplete penetrance ( J:117689 )

• numbers of homozygotes produced is reduced by ~30% from expected numbers; no age when loss occurs is indicated