Analysis Tools
cardiovascular system
| N |
• tamoxifen-treated mice respond similar to wild-type controls in experiments testing response to anaphylactic shock
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Allele Symbol Allele Name Allele ID |
Gna13tm2.1Soff targeted mutation 2.1, Stefan Offermanns MGI:3697690 |
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| Summary |
6 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• tamoxifen-treated mice respond similar to wild-type controls in experiments testing response to anaphylactic shock
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• marginal zone B cell numbers are strongly reduced compared to controls
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• lysophospholipid-induced induced adhesion is completely abrogated in marginal zone mutant B cells and is reduced in follicular B cells
• lysophospholipid-induced induced LFA-1 (integrin) clustering is abolished in mutant B cells
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• marginal zone B cell numbers are strongly reduced compared to controls
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• lysophospholipid-induced induced adhesion is completely abrogated in marginal zone mutant B cells and is reduced in follicular B cells
• lysophospholipid-induced induced LFA-1 (integrin) clustering is abolished in mutant B cells
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• homeostatic CD4+ T cell proliferation is increased within the lymph nodes
• allogenic stimulation of CD4+ T cells is also increased
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• thymus weight and cellularity is increased by about a third
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• CD4+ T cell numbers in the lymph nodes and blood are increased by about a third
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• CD8+ T cell numbers in the lymph nodes are slightly increased
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• CD4+ T cells have longer interactions between themselves and with allogenic dendritic cells
• CD4+ T cells have a higher affinity for ICAM-coated surfaces
• CD4+ T cells have decreased motility through transwell filters
• CD4+ T cells transferred into wild-type mice have enhanced enhanced transendothelial migration into lymph nodes
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• axillary, cervical, inguinal and mesenteric lymph nodes are increased in weight and cell number by about a third
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• an increase in ear thickness is observed after sensitization and challenge with DNFB
• CD4+ T cells in cervical lymph nodes have a higher proliferation rate than those of control mice after DNFB challenge
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• IL-2 secretion is enhanced by CD4+ T cells in response to allogenic stimulation
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• diabetes development is accelerated and aggravated after streptozotocin induction with high glucose levels detected
• peripancreatic lymph nodes are enlarged 5-6 days after disease induction
• increased numbers of CD4+ T cells are noted in the pancreas 14 days after disease induction compared to controls
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• homeostatic CD4+ T cell proliferation is increased within the lymph nodes
• allogenic stimulation of CD4+ T cells is also increased
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• thymus weight and cellularity is increased by about a third
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• CD4+ T cell numbers in the lymph nodes and blood are increased by about a third
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• CD8+ T cell numbers in the lymph nodes are slightly increased
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• CD4+ T cells have longer interactions between themselves and with allogenic dendritic cells
• CD4+ T cells have a higher affinity for ICAM-coated surfaces
• CD4+ T cells have decreased motility through transwell filters
• CD4+ T cells transferred into wild-type mice have enhanced enhanced transendothelial migration into lymph nodes
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• thymus weight and cellularity is increased by about a third
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• homeostatic CD4+ T cell proliferation is increased within the lymph nodes
• allogenic stimulation of CD4+ T cells is also increased
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• platelet thrombus formation is severely impaired ex vivo after treatment of platelets with polyinosinic-polycytidylic acid (PIPC) to induce recombination
• however, initial adhesion of platelets is similar to wild-type
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• serotonin secretion induced by U46619 plus adrenaline or Par-4 peptide exposure is significantly decreased compared to wild-type cells
• however, thrombin-induced serotonin secretion is not impaired
• absence of a shape change in response to low concentration of stimuli compared to wild-type following polyinosinic-polycytidylic acid (PIPC) treatment
• however, shape change is induced with high concentration of stimuli
• potency of agonists to induce aggregation is reduced but aggregation occurs at all agonist concentrations
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• potency of agonists to induce aggregation is reduced but aggregation occurs at all agonist concentrations
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• very large increase in bleeding time in interferon-responsive tissues
• when bone marrow-derived cells PIPC-treated mice are transplanted into irradiated wild-type mice, 4 weeks later mice have greatly prolonged bleeding times (>20 minutes) compared with mice receiving cells from noninduced controls
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• serotonin secretion induced by U46619 plus adrenaline or Par-4 peptide exposure is significantly decreased compared to wild-type cells
• however, thrombin-induced serotonin secretion is not impaired
• absence of a shape change in response to low concentration of stimuli compared to wild-type following polyinosinic-polycytidylic acid (PIPC) treatment
• however, shape change is induced with high concentration of stimuli
• potency of agonists to induce aggregation is reduced but aggregation occurs at all agonist concentrations
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• potency of agonists to induce aggregation is reduced but aggregation occurs at all agonist concentrations
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• tamoxifen-treated mice exhibit decreased blood pressure following treatment with U46619, vasopressin and endothelin compared to in wild-type mice
• tamoxifen-treated mice exposed to DOCA-salt do not develop hypertension and DOCA-salt treated mice exposed to tamoxifen following the onset of hypertension exhibit a drop in blood pressure compared to in similarly treated wild-type mice
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• tamoxifen-treated mice exhibit reduced vasocontraction in response to angiotensin II, U46619 and endothelin-1 compared to in similarly treated wild-type mice
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• tamoxifen-treated mice exhibit reduced vasocontraction in response to angiotensin II, U46619 and endothelin-1 compared to in similarly treated wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• platelet thrombus formation is severely impaired ex vivo after treatment of platelets with polyinosinic-polycytidylic acid (PIPC) to induce recombination
• however, initial adhesion of platelets ex vivo is similar to wild-type
• in wild-type mice transfected with Gna13-deficient bone marrow, after vascular injury no thrombi form
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• impairment in shape change and aggregation induced following polyinosinic-polycytidylic acid (PIPC) treatment is identical to that in mice that are also homozygous for Gna12tm1Citb
• serotonin secretion induced by U46619 plus adrenaline or Par-4 peptide exposure is significantly decreased compared to wild-type cells
• however, thrombin-induced serotonin secretion is not impaired
• in wild-type mice transfected with Gna13-deficient bone marrow, platelets adhere to subendothelial surface after injury, but with a ~50% reduction in numbers compared to wild-type platelets
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• very large increase in bleeding time in interferon-responsive tissues
• when bone marrow-derived cells PIPC-treated mice are transplanted into irradiated wild-type mice, 4 weeks later mice have greatly prolonged bleeding times (>20 minutes) compared with mice receiving cells from noninduced controls
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• impairment in shape change and aggregation induced following polyinosinic-polycytidylic acid (PIPC) treatment is identical to that in mice that are also homozygous for Gna12tm1Citb
• serotonin secretion induced by U46619 plus adrenaline or Par-4 peptide exposure is significantly decreased compared to wild-type cells
• however, thrombin-induced serotonin secretion is not impaired
• in wild-type mice transfected with Gna13-deficient bone marrow, platelets adhere to subendothelial surface after injury, but with a ~50% reduction in numbers compared to wild-type platelets
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 06/12/2024 MGI 6.13 |
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