Phenotypes associated with this allele

• Allele Symbol: Dmrtc2^tm1(cre)Knis
• Allele Name: targeted mutation 1, Katsuhiko Nishimori
• Allele ID: MGI:3697743
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dmrtc2^tm1(cre)Knis/Dmrtc2^tm1(cre)Knis	involves: 129P2/OlaHsd * C57BL/6J	MGI:3699209

Genotype
MGI:3699209

hm1

• Allelic Composition: Dmrtc2^tm1(cre)Knis/Dmrtc2^tm1(cre)Knis
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

small testis ( J:117721 )

♂

testis hypoplasia ( J:117721 )

♂ • testis size and weight are significantly less in mutant mice compared with control mice

abnormal gametogenesis ( J:117721 )

azoospermia ( J:117721 )

♂ • 7 week old mutant mice had no epididymal sperm

abnormal spermatid morphology ( J:117721 )

♂ • spermatids are absent in 7 week old mice

arrest of male meiosis ( J:117721 )

♂ • spermatogenic arrest occurs at the pachytene stage

endocrine/exocrine glands

small testis ( J:117721 )

♂

testis hypoplasia ( J:117721 )

♂ • testis size and weight are significantly less in mutant mice compared with control mice

cellular

azoospermia ( J:117721 )

♂ • 7 week old mutant mice had no epididymal sperm

abnormal spermatid morphology ( J:117721 )

♂ • spermatids are absent in 7 week old mice

arrest of male meiosis ( J:117721 )

♂ • spermatogenic arrest occurs at the pachytene stage