Phenotypes associated with this allele

• Allele Symbol: Tg(Lck-Sox13)#Jskg
• Allele Name: transgene insertion #, Joonsoo Kang
• Allele ID: MGI:3697895
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Lck-Sox13)#Jskg/0	involves: C57BL/6	MGI:3697910

Genotype
MGI:3697910

tg1

• Allelic Composition: Tg(Lck-Sox13)#Jskg/0
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased thymocyte apoptosis ( J:117301 )

• frequency of apoptotic DP and gamma-delta TCR-positive thymocytes is increased 2-fold compared to littermates

decreased T cell proliferation ( J:117301 )

• a 2.5-fold decrease in BrdU incorporation is observed in thymocyte progenitors (triple negative (TN) cells)

decreased thymocyte number ( J:117301 )

• total thymocyte numbers are greatly reduced compared to littermate controls

decreased double-positive T cell number ( J:117301 )

• double-positive (DP) T cells are absent or nearly so in E17 transgenic mice and their development remains impaired through adult life

hematopoietic system

increased thymocyte apoptosis ( J:117301 )

• frequency of apoptotic DP and gamma-delta TCR-positive thymocytes is increased 2-fold compared to littermates

decreased T cell proliferation ( J:117301 )

• a 2.5-fold decrease in BrdU incorporation is observed in thymocyte progenitors (triple negative (TN) cells)

decreased thymocyte number ( J:117301 )

• total thymocyte numbers are greatly reduced compared to littermate controls

decreased double-positive T cell number ( J:117301 )

• double-positive (DP) T cells are absent or nearly so in E17 transgenic mice and their development remains impaired through adult life

cellular

increased thymocyte apoptosis ( J:117301 )

• frequency of apoptotic DP and gamma-delta TCR-positive thymocytes is increased 2-fold compared to littermates

decreased T cell proliferation ( J:117301 )

• a 2.5-fold decrease in BrdU incorporation is observed in thymocyte progenitors (triple negative (TN) cells)

endocrine/exocrine glands

increased thymocyte apoptosis ( J:117301 )

• frequency of apoptotic DP and gamma-delta TCR-positive thymocytes is increased 2-fold compared to littermates

decreased thymocyte number ( J:117301 )

• total thymocyte numbers are greatly reduced compared to littermate controls